Department of Gastroenterology, Second Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Sci Rep. 2022 Aug 17;12(1):13969. doi: 10.1038/s41598-022-18197-6.
Metabolic-associated fatty liver disease (MAFLD) is currently the most common chronic liver disease worldwide and the main cause of hepatocellular carcinoma (HCC). To explore the risk factors of MAFLD-HCC, we evaluated the independent and combined effects of metabolic characteristics on the risk of MAFLD-HCC. We retrospectively analyzed 135 MAFLD-HCC patients who were treated at the Second Affiliated Hospital of Kunming Medical University from January 2015 to December 2020 and 135 MAFLD patients as the control group. Independent and joint effects of metabolic traits on the risk of HCC were evaluated. Each metabolic feature was significantly correlated with the increased risk of MAFLD-HCC (p < 0.05); obesity had the strongest correlation (adjusted odds ratio [OR] 3.63, 95% confidence interval [CI] 1.99-6.62). In patients with superimposed features, HCC risk was higher with more metabolic features (p < 0.05). The correlation between metabolic characteristics and risk of MAFLD-HCC in patients without cirrhosis or advanced fibrosis was basically consistent with the overall analysis. Metabolic characteristics increase the risk of MAFLD-HCC, and the risk is positively correlated with the number of metabolic characteristics. Obesity has the strongest correlation with HCC.
代谢相关性脂肪性肝病（MAFLD）是目前全球最常见的慢性肝病，也是肝细胞癌（HCC）的主要病因。为了探讨 MAFLD-HCC 的危险因素，我们评估了代谢特征对 MAFLD-HCC 风险的独立和联合作用。我们回顾性分析了 2015 年 1 月至 2020 年 12 月在昆明医科大学第二附属医院治疗的 135 例 MAFLD-HCC 患者和 135 例 MAFLD 患者作为对照组。评估了代谢特征对 HCC 风险的独立和联合作用。每个代谢特征均与 MAFLD-HCC 风险增加显著相关（p<0.05）；肥胖相关性最强（调整后比值比[OR]3.63，95%置信区间[CI]1.99-6.62）。在叠加特征的患者中，具有更多代谢特征的患者 HCC 风险更高（p<0.05）。在无肝硬化或晚期纤维化的患者中，代谢特征与 MAFLD-HCC 风险之间的相关性与总体分析基本一致。代谢特征增加了 MAFLD-HCC 的风险，且风险与代谢特征的数量呈正相关。肥胖与 HCC 的相关性最强。
