Department of Interdisciplinary Dentistry, Pomeranian Medical University, Al. Powstańców Wlkp. 72, 70-111, Szczecin, Poland.
Institute of Mother and Child, Warsaw, Poland.
Sci Rep. 2022 Aug 17;12(1):13985. doi: 10.1038/s41598-022-18107-w.
This randomized, parallel, controlled trial assessed the effect of fluoride varnish, ozone and octenidine on white spot lesions (WSLs) and caries during orthodontic treatment. Patients were enrolled between 1st September 2017 and 31st August 2020 at initiation of orthodontic treatment in Department of Interdisciplinary Dentistry Pomeranian Medical University in Szczecin, Poland. All participants were randomly assigned to four study and one control groups using number random generator. However, investigators were not blinded due to the nature of the study. Groups I, II, III, IV had professional cleaning and varnishing (5% NaF) every 4 weeks. Groups II and IV had in-office ozone therapy before varnishing, groups III and IV received domestic octenidine mouthrinse. Group K had no professional hygienic or prophylactic procedures. WSLs were assessed at T0 and then every 4 weeks (T1-T4) and caries-at T0 and T4. The specific objective was to assess the influence of fluoride varnish, ozone and octenidine on the incidence of white spot lesions and caries during orthodontic treatment. The primary outcome of this report was the highest number of WSLs in group K and the lowest percentage of patients with WSLs in group IV. Each group comprised 30 randomized participants; they were all analyzed. No WSLs were found at T0, but they were stated in all groups at T4. The numbers of patients with WSLs significantly increased between T0-T4 in groups I and K. Group IV had the lowest percentage of patients with WSLs in T1-T4. WSLs in group IV were found no earlier than at T2. Group K had the highest percentage of WSLs at T4: 26%. At T0 all the groups had DMFs above 0 with a significant increase at T4. No side effects of the introduced prophylaxis were observed in any group. Caries is an important problem of fixed orthodontic treatment. Even an extremely intensive prophylaxis could not completely prevent WSLs and caries. Simultaneous application of fluoride varnish, ozone gas exposure and octenidine appears to have a beneficial effect in limiting the development of WSLs.Trial registration: NCT04992481.
这项随机、平行、对照试验评估了氟化物漆、臭氧和奥替尼啶在正畸治疗期间对白垩斑（WSL）和龋齿的影响。2017 年 9 月 1 日至 2020 年 8 月 31 日，波兰什切青波美尼亚医科大学跨学科牙科系在开始正畸治疗时招募了患者。所有参与者均使用数字随机发生器随机分配至四个研究组和一个对照组。然而，由于研究的性质，研究人员无法进行盲法。I 组、II 组、III 组和 IV 组每 4 周进行一次专业清洁和涂漆（5% NaF）。II 组和 IV 组在涂漆前进行诊室臭氧治疗，III 组和 IV 组接受家庭用奥替尼啶漱口。K 组不进行专业卫生或预防程序。WSL 在 T0 时进行评估，然后每 4 周（T1-T4）评估一次，T0 和 T4 时评估龋齿。具体目标是评估氟化物漆、臭氧和奥替尼啶对正畸治疗期间白垩斑和龋齿发生率的影响。本报告的主要结果是 K 组中 WSL 数量最多，IV 组中 WSL 患者比例最低。每组均有 30 名随机参与者；所有参与者均进行了分析。T0 时未发现 WSL，但在 T4 时所有组均有 WSL 报告。I 组和 K 组 T0-T4 期间 WSL 患者数量显著增加。IV 组在 T1-T4 期间 WSL 患者比例最低。IV 组的 WSL 直到 T2 时才出现。K 组在 T4 时的 WSL 比例最高：26%。T0 时所有组的 DMFS 均大于 0，T4 时显著增加。任何组均未观察到引入的预防措施的副作用。龋齿是固定正畸治疗的一个重要问题。即使采用极其强化的预防措施，也不能完全预防 WSL 和龋齿。氟化物漆、臭氧暴露和奥替尼啶的同时应用似乎对限制 WSL 发展具有有益作用。试验注册：NCT04992481。
