Departments of Intensive Care for Consciousness Rehabilitation and Spinal Rehabilitation, Loewenstein Rehabilitation Medical Center, Raanana, Israel.
Sackler Faculty of Medicine, Rehabilitation Department, Tel Aviv University, Tel Aviv, Israel.
Brain Inj. 2022 Jul 29;36(9):1167-1175. doi: 10.1080/02699052.2022.2110286. Epub 2022 Aug 17.
Sensory stimulation in Snoezelen room increased responsiveness after brain injury and dementia.
To explore the physiological and clinical effects of Snoezelen stimulation in persons with unresponsive wakefulness syndrome or minimally conscious state (UWS or MCS).
A comparative prospective observational cohort study.
Ten patients with UWS and 25 in MCS were exposed to consecutive stimuli involving the 5 senses in a Snoezelen room. Heart rate (HR) and cerebral blood flow velocity (CBFV), and scores of the Loewenstein communication scale (LCS) were obtained before and during or after the stimuli.
The stimuli increased HR values and decreased left hemisphere CBFV values in patients with MCS (p < 0.05). Stimulation increased LCS scores (from 28.48 ± 6.55 to 31.13 ± 7.14; p < 0.001) in patients with MCS, but not in the UWS group. LCS gain correlated with HR and right hemisphere CBFV gains in patients with MCS (r = 0.439 and 0.636 respectively, p < 0.05).
Snoezelen stimulation induced immediate improvement in communication and physiological changes in patients with MSC, and had a minor physiological effect in patients with UWS. If additional studies support these findings, it will be possible to suggest that Snoezelen stimulation can affect arousal, and possibly improve functioning.
感官刺激在感官刺激室中增加了脑损伤和痴呆后的反应能力。
探讨感官刺激对无反应性觉醒综合征或最小意识状态（UWS 或 MCS）患者的生理和临床影响。
一项比较前瞻性观察队列研究。
10 名 UWS 患者和 25 名 MCS 患者在感官刺激室中连续接受涉及 5 种感觉的刺激。在刺激前后，获得心率（HR）和大脑血流速度（CBFV）以及 Loewenstein 沟通量表（LCS）的评分。
刺激增加了 MCS 患者的 HR 值，并降低了左半球的 CBFV 值（p < 0.05）。刺激使 MCS 患者的 LCS 评分增加（从 28.48 ± 6.55 增加到 31.13 ± 7.14；p < 0.001），但对 UWS 组没有影响。MCS 患者的 LCS 增益与 HR 和右半球 CBFV 增益相关（r = 0.439 和 0.636，分别为 p < 0.05）。
感官刺激立即改善了 MCS 患者的沟通和生理变化，并对 UWS 患者产生了较小的生理影响。如果进一步的研究支持这些发现，那么就有可能表明感官刺激可以影响觉醒，并可能改善功能。
