He Zhen, Yuan Bo
Department of Pediatrics, The No. 2 Hospital of Baoding, Baoding, China.
Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, China.
Evid Based Complement Alternat Med. 2022 Aug 8;2022:7928344. doi: 10.1155/2022/7928344. eCollection 2022.
To study the diagnostic value of combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels in children with idiopathic central precocious puberty (ICPP).
30 cases of children with ICPP admitted to our hospital from January 2019 to January 2021 were selected as the experimental group, and 30 healthy people during the same period were selected as the control group. Both groups received pelvic ultrasound and serum LH, FSH, and E2 detection; the two groups were compared in terms of serum indicators, combined diagnosis, specificity, and sensitivity.
There were statistical differences in height, leptin, bone age, and areola diameter between the two groups ( < 0.05). The length of the uterus, the volume of the uterus, the area of the ovary, the volume of the ovary, and the maximum diameter of the follicle in the experimental group were larger than those in the control group ( < 0.05). The endometrial thickness of the experimental group was significantly greater than that of the control group ( < 0.05). The levels of serum LH, FSH, and E2 in the experimental group were significantly higher than those in the control group ( < 0.05). The area of the combined detection was significantly larger than that of the single detection. The combined detection was superior to the single detection with respect to the area, standard error a, asymptotic Sig. B, and asymptotic 95% confidence interval ( < 0.05). The sensitivity of the combined detection was significantly higher than that of the single detection.
The combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels may be a preferred technique for the diagnosis of children with ICPP due to its benefits of high sensitivity and accuracy. It is worthy of clinical promotion and application.
探讨盆腔超声联合血清促黄体生成素(LH)、促卵泡生成素(FSH)及雌二醇(E2)水平检测对特发性中枢性性早熟(ICPP)患儿的诊断价值。
选取2019年1月至2021年1月我院收治的30例ICPP患儿作为实验组,选取同期30例健康人作为对照组。两组均接受盆腔超声及血清LH、FSH、E2检测;比较两组的血清指标、联合诊断、特异性及敏感性。
两组身高、瘦素、骨龄及乳晕直径比较,差异有统计学意义(<0.05)。实验组子宫长度、子宫体积、卵巢面积、卵巢体积及卵泡最大直径均大于对照组(<0.05)。实验组子宫内膜厚度明显大于对照组(<0.05)。实验组血清LH、FSH、E2水平明显高于对照组(<0.05)。联合检测面积明显大于单项检测。联合检测在面积、标准误a、渐近显著性B及渐近95%置信区间方面优于单项检测(<0.05)。联合检测的敏感性明显高于单项检测。
盆腔超声联合血清LH、FSH、E2水平检测可能是诊断ICPP患儿的首选技术,因其具有高敏感性和准确性的优点。值得临床推广应用。