Jiang Mei, Gao Ying, Huang Ling
Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Department of Acupuncture, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Pediatr Res. 2025 May 12. doi: 10.1038/s41390-025-03976-4.
This meta-analysis aimed to assess circulating adipokine levels in girls with central precocious puberty (CPP) and compare them with those in healthy controls.
An exhaustive literature search was conducted, using the Embase, PubMed, Web of Science, Cochrane Library, and Scopus databases, from the inception of the study to October 31, 2023, to identify relevant studies. Studies comparing the serum levels of adiponectin, leptin, irisin, apelin, omentin,chemerin, resistin, vaspin, and visfatin in girls with CPP and healthy girls of the same age were included. The findings were summarized in Grading of Recommendations Assessment, Development, and Evaluation evidence profiles and synthesized qualitatively.
Eleven studies that included 701 girls with CPP and 590 healthy girls were analyzed after the selection process. Leptin levels were significantly increased, whereas adiponectin levels were decreased in girls with CPP. Irisin levels did not change significantly. Subgroup and meta-regression analyses indicated that the heterogeneity in the association of leptin with CPP might be due to factors such as the number of cases, diagnostic criteria for CPP, and measurement methods.
Adipokines levels were altered in girls with CPP compared with those in healthy controls. Preventing obesity in children and adolescents with CPP is crucial.
CRD42022371490.
This meta-analysis is the first to explore the relationship between adipokines and central precocious puberty. The results of this systematic review provide evidence that adipokines levels are altered in girls with central precocious puberty (CPP) compared with those in healthy controls. CPP in girls increases the risk of cardiovascular disease in adulthood. Preventing obesity in children and adolescents, especially in those with precocious puberty, is crucial.
本荟萃分析旨在评估中枢性性早熟（CPP）女童的循环脂肪因子水平，并将其与健康对照者的水平进行比较。
从研究开始至2023年10月31日，使用Embase、PubMed、Web of Science、Cochrane图书馆和Scopus数据库进行了详尽的文献检索，以确定相关研究。纳入比较CPP女童与同龄健康女童血清脂联素、瘦素、鸢尾素、脂联素、网膜素、趋化素、抵抗素、内脏脂肪素和内脂素水平的研究。研究结果汇总在推荐评估、制定和评价证据分级概况中，并进行定性综合分析。
经过筛选过程，分析了11项研究，其中包括701名CPP女童和590名健康女童。CPP女童的瘦素水平显著升高，而脂联素水平降低。鸢尾素水平无显著变化。亚组和Meta回归分析表明，瘦素与CPP关联的异质性可能归因于病例数、CPP诊断标准和测量方法等因素。
与健康对照者相比，CPP女童的脂肪因子水平发生了改变。预防CPP儿童和青少年肥胖至关重要。
PROSPERO注册号：CRD42022371490。
本荟萃分析首次探讨了脂肪因子与中枢性性早熟之间的关系。该系统评价的结果提供了证据，表明与健康对照者相比，中枢性性早熟（CPP）女童的脂肪因子水平发生了改变。女童CPP会增加成年后患心血管疾病的风险。预防儿童和青少年肥胖，尤其是性早熟儿童和青少年的肥胖至关重要。
