腺病毒载量对儿童腺病毒肺炎支气管黏液栓形成的预测价值。

Predictive Value of Adenoviral Load for Bronchial Mucus Plugs Formation in Children with Adenovirus Pneumonia.

机构信息

Hunan Provincial Key Laboratory of Pediatric Respirology, Pediatric Medical Center, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, China.

出版信息

Can Respir J. 2022 Aug 8;2022:9595184. doi: 10.1155/2022/9595184. eCollection 2022.

DOI:10.1155/2022/9595184

PMID:35979256

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9377942/

Abstract

BACKGROUND

The study aimed to explore risk factors for bronchial mucus plugs (BMP) formation in children with adenovirus (AdV) pneumonia.

METHODS

A retrospective study was conducted on children with AdV pneumonia who underwent bronchoscopy from January 2019 to December 2019. Children were divided into the BMP group and the control group, depending on whether BMP was formed or not. The clinical information and treatment proposals of the two groups of children were counted and analyzed via multiple logistic regression analysis, ROC curve analysis, and correlation analysis.

RESULTS

Among 453 patients with AdV pneumonia, 185 (40.84%) were in the BMP group. Among all the cases, there were 188 patients with a single AdV infection, including 64 (34.04%) in the BMP group and 124 (65.96%) in the control group. The incidence of dyspnea, poor spirits, mixed infections, and other symptoms in the BMP group was higher than in the control group. Children in the BMP group had a longer heat range. C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), and AdV load levels were higher in the MBP group. AdV load, coinfection, DD, heat range, and LDH were independent risk factors for BMP, among which AdV load was the most significant (AUC = 0.819). AdV load was positively correlated with other risk factors, respectively. AdV load and heat range were independent risk factors for BMP patients with a single AdV infection.

CONCLUSION

AdV load might have important clinical value in predicting BMP development in AdV pneumonia.

摘要

背景

本研究旨在探讨腺病毒（AdV）肺炎患儿支气管黏液栓（BMP）形成的危险因素。

方法

对 2019 年 1 月至 2019 年 12 月接受支气管镜检查的 AdV 肺炎患儿进行回顾性研究。根据是否形成 BMP，将患儿分为 BMP 组和对照组。对两组患儿的临床资料和治疗方案进行计数和分析，并通过多因素 logistic 回归分析、ROC 曲线分析和相关性分析。

结果

在 453 例 AdV 肺炎患儿中，185 例（40.84%）形成 BMP。在所有病例中，单纯 AdV 感染 188 例，其中 BMP 组 64 例（34.04%），对照组 124 例（65.96%）。BMP 组呼吸困难、精神不振、混合感染等症状发生率高于对照组。BMP 组患儿发热时间较长。BMP 组 C 反应蛋白（CRP）、乳酸脱氢酶（LDH）、D-二聚体（DD）和 AdV 载量水平较高。AdV 载量、混合感染、DD、发热时间和 LDH 是 BMP 的独立危险因素，其中 AdV 载量最显著（AUC=0.819）。AdV 载量与其他危险因素呈正相关。AdV 载量和发热时间是单纯 AdV 感染患儿 BMP 的独立危险因素。