Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2022 Aug 1;13:900826. doi: 10.3389/fimmu.2022.900826. eCollection 2022.
Interleukin-33 (IL-33) is a pleiotropic cytokine linked to various immune cells in the innate and adaptive immune systems. Recent studies of the effects of IL-33 on immune cells are beginning to reveal its regulatory mechanisms at the levels of cellular metabolism and epigenetic modifications. In response to IL-33 stimulation, these programs are intertwined with transcriptional programs, ultimately determining the fate of immune cells. Understanding these specific molecular events will help to explain the complex role of IL-33 in immune cells, thereby guiding the development of new strategies for immune intervention. Here, we highlight recent findings that reveal how IL-33, acting as an intracellular nuclear factor or an extracellular cytokine, alters metabolic checkpoints and cellular metabolism, which coordinately contribute to cell growth and function. We also discuss recent studies supporting the role of IL-33 in epigenetic alterations and speculate about the mechanisms underlying this relationship.
白细胞介素 33（IL-33）是一种多功能细胞因子，与先天和适应性免疫系统中的各种免疫细胞有关。最近对 IL-33 对免疫细胞影响的研究开始揭示其在细胞代谢和表观遗传修饰水平的调节机制。在对 IL-33 刺激的反应中，这些程序与转录程序交织在一起，最终决定免疫细胞的命运。了解这些特定的分子事件将有助于解释 IL-33 在免疫细胞中的复杂作用，从而为免疫干预的新策略的发展提供指导。在这里，我们重点介绍了最近的发现，这些发现揭示了 IL-33 作为细胞内核因子或细胞外细胞因子如何改变代谢检查点和细胞代谢，从而共同促进细胞生长和功能。我们还讨论了支持 IL-33 在表观遗传改变中作用的最近研究，并推测了这种关系的潜在机制。
