Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, IRCCS Humanitas Research Hospital, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Front Endocrinol (Lausanne). 2022 Aug 1;13:907249. doi: 10.3389/fendo.2022.907249. eCollection 2022.
The management of infertile women affected by hypogonadotropic hypogonadism (HH) or conditions mimicking it is particularly challenging. In the present narrative review, we aimed to synthesize the available evidence on the benefit (if any) of exogenous luteinizing hormone (LH) supplementation in this group of patients. Available data support LH supplementation in women with organic or functional HH. On the contrary, the benefit of exogenous LH on reproductive outcomes both in advanced maternal age patients and in cases of depletion of FSH and LH levels induced by GnRH analogues has not been demonstrated. unfortunately, the inhomogeneous study populations as well as the methodological heterogeneity between studies focused on women affected by conditions mimicking HH do not allow reliable conclusions to be drawn.
患有促性腺激素低下性性腺功能减退症（HH）或类似病症的不孕女性的管理尤其具有挑战性。在本叙述性综述中，我们旨在综合现有关于外源性黄体生成素（LH）补充对这群患者的益处（如果有的话）的证据。现有数据支持对有机或功能性 HH 患者进行 LH 补充。相反，外源性 LH 对高龄产妇和 GnRH 类似物诱导的 FSH 和 LH 水平下降的情况下的生殖结局的益处尚未得到证实。不幸的是，由于研究人群的异质性以及针对类似 HH 病症的女性的研究之间的方法学异质性，无法得出可靠的结论。
