Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Aug 1;13:935980. doi: 10.3389/fendo.2022.935980. eCollection 2022.
The purpose of the study was to determine the correlation of the Chinese visceral adiposity index (CVAI) with metabolic-associated fatty liver disease (MAFLD) in Chinese adults with type 2 diabetes mellitus (T2DM).
MATERIALS/METHODS: In this cross-sectional study, data on sociodemographic characteristics, laboratory test results, coexisting diseases, and medical therapy were collected and analyzed. Multivariate logistic regression analyses were used to examine the correlation between CVAI and MAFLD. In order to investigate the correlation between CVAI on a continuous scale and MAFLD, a restricted cubic spline (RCS) was used.
A total of 679 participants were included in this study. There were 251 female participants and 428 male participants, with a median age of 55 years. In the multivariate logistic regression model, diastolic blood pressure, duration of diabetes, glycated hemoglobin, hemoglobin, alanine transaminase, aspartate aminotransferase, gamma -glutamyl transferase, albumin, blood urea nitrogen, total cholesterol, low-density lipoprotein cholesterol, statin use and metformin use were adjusted, and an evident increase in the odds ratios of MAFLD from the lowest to the highest CVAI quartile was found ( value for trend < 0.001). Moreover, the RCS curves revealed a positive correlation between CVAI and MAFLD.
The CVAI is positively correlated with MAFLD and may be an indicator with diagnostic value for MAFLD in clinical practice in type 2 diabetic patients.
本研究旨在探讨中国内脏脂肪指数（CVAI）与中国 2 型糖尿病（T2DM）患者代谢相关脂肪性肝病（MAFLD）的相关性。
材料/方法：本横断面研究收集并分析了社会人口统计学特征、实验室检查结果、并存疾病和药物治疗的数据。采用多变量逻辑回归分析来检验 CVAI 与 MAFLD 之间的相关性。为了研究 CVAI 连续尺度与 MAFLD 之间的相关性，采用了受限立方样条（RCS）。
共纳入 679 名参与者，其中女性 251 名，男性 428 名，中位年龄为 55 岁。在多变量逻辑回归模型中，调整了舒张压、糖尿病病程、糖化血红蛋白、血红蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、γ-谷氨酰转移酶、白蛋白、尿素氮、总胆固醇、低密度脂蛋白胆固醇、他汀类药物和二甲双胍的使用情况，发现 MAFLD 的比值比从最低到最高 CVAI 四分位组呈明显升高趋势（趋势值<0.001）。此外，RCS 曲线显示 CVAI 与 MAFLD 呈正相关。
CVAI 与 MAFLD 呈正相关，可能是临床实践中诊断 2 型糖尿病患者 MAFLD 的有价值指标。
