COVID-19 感染后和最近使用编码 SARS-CoV-2 刺突蛋白抗原的重组腺病毒载体（ChAdOx1 nCoV-19，Vaxzevria）进行新冠病毒疫苗接种后的成人多系统炎症综合征（MIS-A）
Multisystem Inflammatory Syndrome in Adults (MIS-A) After COVID-19 Infection and Recent Vaccination with Recombinant Adenoviral Vector Encoding the Spike Protein Antigen of SARS-CoV-2 (ChAdOx1 nCoV-19, Vaxzevria).
机构信息
Department of Surgery, Radiology Anaesthesia and Intensive Care, 62707University of the West Indies, Mona, Jamaica.
University Hospital of the West Indies, Mona, Jamaica.
出版信息
J Intensive Care Med. 2023 Feb;38(2):232-237. doi: 10.1177/08850666221121589. Epub 2022 Aug 17.
Abstract
The clinical spectrum of Coronavirus 2019 (COVID-19) includes acute COVID-19, long covid and multisystem inflammatory syndrome in children and adults (MISC/A). The rapid roll-out of COVID-19 vaccination has the potential to affect the clinical presentation of COVID-19 and case reports document rare occurrences of MIS-A after COVID-19 infection and recent vaccination with m-RNA vaccines. We describe 2 cases of MIS-A after COVID-19 infection and recent vaccination with ChAdOx1 nCoV-19.
摘要
新型冠状病毒（COVID-19）的临床谱包括急性 COVID-19、长期 COVID-19 和儿童及成人多系统炎症综合征（MISC/A）。COVID-19 疫苗的快速推出可能会影响 COVID-19 的临床表现，病例报告记录了 COVID-19 感染后和最近接种 m-RNA 疫苗后罕见的 MIS-A 发生情况。我们描述了两例 COVID-19 感染后和最近接种 ChAdOx1 nCoV-19 后发生的 MIS-A 病例。
相似文献
1
Multisystem Inflammatory Syndrome in Adults (MIS-A) After COVID-19 Infection and Recent Vaccination with Recombinant Adenoviral Vector Encoding the Spike Protein Antigen of SARS-CoV-2 (ChAdOx1 nCoV-19, Vaxzevria).COVID-19 感染后和最近使用编码 SARS-CoV-2 刺突蛋白抗原的重组腺病毒载体（ChAdOx1 nCoV-19，Vaxzevria）进行新冠病毒疫苗接种后的成人多系统炎症综合征（MIS-A）
J Intensive Care Med. 2023 Feb;38(2):232-237. doi: 10.1177/08850666221121589. Epub 2022 Aug 17.
2
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.腺病毒载体新冠疫苗（ChAdOx1 nCoV-19）对严重急性呼吸综合征冠状病毒 2 （SARS-CoV-2）的安全性和免疫原性：一项 1/2 期、单盲、随机对照临床试验的初步报告。
Lancet. 2020 Aug 15;396(10249):467-478. doi: 10.1016/S0140-6736(20)31604-4. Epub 2020 Jul 20.
3
Evaluation of Humoral Immune Response after SARS-CoV-2 Vaccination Using Two Binding Antibody Assays and a Neutralizing Antibody Assay.评价两种结合抗体检测试剂盒和中和抗体检测试剂盒在评估 SARS-CoV-2 疫苗接种后的体液免疫应答中的应用。
Microbiol Spectr. 2021 Dec 22;9(3):e0120221. doi: 10.1128/Spectrum.01202-21. Epub 2021 Nov 24.
4
Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes (VIVALDI): an observational study.BNT162b2 或 ChAdOx1 nCoV-19 疫苗单剂接种后在居住护理院居民和工作人员中的体液和细胞免疫应答特征（VIVALDI）：一项观察性研究。
Lancet Healthy Longev. 2021 Sep;2(9):e544-e553. doi: 10.1016/S2666-7568(21)00168-9. Epub 2021 Aug 19.
5
MOG encephalomyelitis after vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2): case report and comprehensive review of the literature.接种 2019 年冠状病毒病（SARS-CoV-2）疫苗后发生 MOG 脑炎：病例报告及文献综述。
J Neurol. 2022 Oct;269(10):5198-5212. doi: 10.1007/s00415-022-11194-9. Epub 2022 Jun 23.
6
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.在一项 1/2 期临床试验中，单次接种 ChAdOx1 nCoV-19（AZD1222）疫苗诱导的 T 细胞和抗体反应。
Nat Med. 2021 Feb;27(2):270-278. doi: 10.1038/s41591-020-01194-5. Epub 2020 Dec 17.
7
A phase 3 randomized controlled trial of a COVID-19 recombinant vaccine S-268019-b versus ChAdOx1 nCoV-19 in Japanese adults.一项评估 COVID-19 重组疫苗 S-268019-b 与 ChAdOx1 nCoV-19 在日本成年人中免疫效果的 3 期随机对照试验
Sci Rep. 2024 Apr 29;14(1):9830. doi: 10.1038/s41598-024-57308-3.
8
Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.新冠病毒疫苗接种后和 SARS-CoV-2 阳性检测后的血小板减少症和血栓栓塞风险：自身对照病例系列研究。
BMJ. 2021 Aug 26;374:n1931. doi: 10.1136/bmj.n1931.
9
Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways.接种 SARS-CoV-2 疫苗后发生的凝血功能障碍可能源于 SARS-CoV-2 刺突蛋白和腺病毒载体触发的信号通路的综合作用。
Int J Mol Sci. 2021 Oct 6;22(19):10791. doi: 10.3390/ijms221910791.
10
Interdependencies of cellular and humoral immune responses in heterologous and homologous SARS-CoV-2 vaccination.细胞和体液免疫应答在异源和同源 SARS-CoV-2 疫苗接种中的相互关系。
Allergy. 2022 Aug;77(8):2381-2392. doi: 10.1111/all.15247. Epub 2022 Feb 16.
引用本文的文献
1
Concomitant Cytomegalovirus Viraemia in Multisystem Inflammatory Syndrome in Adults (MIS-A) following COVID-19.成人多系统炎症综合征（MIS-A）患者在新型冠状病毒肺炎（COVID-19）后出现的巨细胞病毒血症
Case Rep Infect Dis. 2024 Apr 1;2024:8852063. doi: 10.1155/2024/8852063. eCollection 2024.
2
First confirmed case of multisystem inflammatory syndrome in adult in Egypt.埃及首例成人多系统炎症综合征确诊病例。
Clin Case Rep. 2023 May 31;11(6):e7382. doi: 10.1002/ccr3.7382. eCollection 2023 Jun.
3
Letter to the Editor: There Is No Indication for Treating Long COVID Vaccination Syndrome With Colchicine.致编辑的信：没有迹象表明秋水仙碱可用于治疗新冠长期疫苗接种综合征。
J Korean Med Sci. 2022 Dec 26;37(50):e357. doi: 10.3346/jkms.2022.37.e357.
本文引用的文献
1
Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves.南非在 COVID-19 奥密克戎变异株流行期间住院患者的特征和结局与前几波相比。
JAMA. 2022 Feb 8;327(6):583-584. doi: 10.1001/jama.2021.24868.
2
A case of multisystem inflammatory syndrome in adults following natural infection and subsequent immunization.成人自然感染后再接种疫苗引发的多系统炎症综合征病例
Int J Infect Dis. 2022 Mar;116:34-37. doi: 10.1016/j.ijid.2021.12.339. Epub 2021 Dec 24.
3
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.与 COVID-19 疫苗接种或 SARS-CoV-2 感染相关的心肌炎、心包炎和心律失常风险。
Nat Med. 2022 Feb;28(2):410-422. doi: 10.1038/s41591-021-01630-0. Epub 2021 Dec 14.
4
Long covid-mechanisms, risk factors, and management.长新冠的发病机制、危险因素和管理。
BMJ. 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648.
5
COVID-19 mRNA Vaccine and Myocarditis.新冠病毒信使核糖核酸疫苗与心肌炎
Eur J Case Rep Intern Med. 2021 Jun 14;8(7):002681. doi: 10.12890/2021_002681. eCollection 2021.
6
Multisystem Inflammatory Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccination.感染 SARS-CoV-2 后的多系统炎症综合征和 COVID-19 疫苗接种。
Emerg Infect Dis. 2021 Jul;27(7):1944-1948. doi: 10.3201/eid2707.210594. Epub 2021 May 25.
7
Characteristics Associated With Multisystem Inflammatory Syndrome Among Adults With SARS-CoV-2 Infection.与 SARS-CoV-2 感染成人中多系统炎症综合征相关的特征。
JAMA Netw Open. 2021 May 3;4(5):e2110323. doi: 10.1001/jamanetworkopen.2021.10323.
8
COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials.新型冠状病毒肺炎疫苗：当前临床试验安全性与有效性综述
Pharmaceuticals (Basel). 2021 Apr 25;14(5):406. doi: 10.3390/ph14050406.
9
Adult multisystem inflammatory syndrome in a patient who recovered from COVID-19 postvaccination.接种新冠疫苗后康复的患者出现成人多系统炎症综合征。
BMJ Case Rep. 2021 Apr 21;14(4):e242060. doi: 10.1136/bcr-2021-242060.
10
Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.接种 ChAdOx1 nCov-19 疫苗后发生血栓性血小板减少症。
N Engl J Med. 2021 Jun 3;384(22):2092-2101. doi: 10.1056/NEJMoa2104840. Epub 2021 Apr 9.
Zotero 插件