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长新冠的发病机制、危险因素和管理。

Long covid-mechanisms, risk factors, and management.

机构信息

Faculty of Medicine, Imperial College London, London, UK.

Faculty of Medicine, Imperial College London, London, UK

出版信息

BMJ. 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648.


DOI:10.1136/bmj.n1648
PMID:34312178
Abstract

Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is now coined long covid by recognized research institutes. Studies have shown that long covid can affect the whole spectrum of people with covid-19, from those with very mild acute disease to the most severe forms. Like acute covid-19, long covid can involve multiple organs and can affect many systems including, but not limited to, the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. The symptoms of long covid include fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of post-traumatic stress disorder, muscle pain, concentration problems, and headache. This review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure. Risk factors for acute covid-19 and long covid and possible therapeutic options are also discussed.

摘要

自 2019 年底在中国武汉出现以来,新冠病毒(covid-19)在全球范围内传播,并对人们的生活和健康产生了深远影响。截至 2021 年 7 月 4 日,全球已记录超过 1.83 亿例 covid-19 确诊病例,397 万人死亡。最近的证据表明,在急性 SARS-CoV-2 感染后,许多人会持续出现一系列症状,现在被认可的研究机构称为“长新冠(long covid)”。研究表明,长新冠(long covid)会影响到感染新冠病毒(covid-19)的所有人,从轻症到重症患者。长新冠(long covid)的症状与急性新冠(covid-19)相似,可累及多个器官,可影响包括但不限于呼吸系统、心血管系统、神经系统、胃肠道和肌肉骨骼系统在内的多个系统。长新冠(long covid)的症状包括疲劳、呼吸困难、心脏异常、认知障碍、睡眠障碍、创伤后应激障碍症状、肌肉疼痛、注意力问题和头痛。这篇综述总结了对住院和非住院患者新冠长期影响的研究,并描述了他们所忍受的持续症状。还讨论了急性新冠和长新冠的风险因素以及可能的治疗选择。

相似文献

[1]
Long covid-mechanisms, risk factors, and management.

BMJ. 2021-7-26

[2]
[Long COVID: nosographic aspects and clinical epidemiology].

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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J R Soc Med. 2021-9

[10]
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Cephalalgia. 2021-11

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[2]
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Commun Biol. 2025-8-29

[3]
Multiorgan Involvement and Particularly Liver Injury in Long COVID: A Narrative Review.

Life (Basel). 2025-8-19

[4]
Consensus based recommendations for the management of post-COVID long-term sequelae (Long COVID): a regional perspective.

Front Med (Lausanne). 2025-8-6

[5]
Association Between Acute COVID-19 Infection and Long COVID in a Non-Hospitalized Population: A Retrospective Case-Control Study.

Health Sci Rep. 2025-8-18

[6]
Long COVID Optimal Health Programme to Enhance Mental and Physical Health: A Feasibility Randomised Controlled Trial.

Health Expect. 2025-8

[7]
Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the Research Program.

medRxiv. 2025-8-12

[8]
MicroRNAs in long COVID: roles, diagnostic biomarker potential and detection.

Hum Genomics. 2025-8-13

[9]
Oral manifestations of COVID-19 vaccinated individuals, post-infection, and different variants: a Brazilian population study.

Braz Oral Res. 2025-8-4

[10]
Coping with long-COVID stigma: The role of self-compassion and self-coldness.

Health Psychol Open. 2025-7-26

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