Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Coron Artery Dis. 2022 Dec 1;33(8):655-660. doi: 10.1097/MCA.0000000000001183. Epub 2022 Aug 17.
This study aimed to compare the profiles of young and very young patients with coronary artery disease (CAD) and explore the factors associated with acute myocardial infarction (AMI) based on age.
Young CAD patients aged between 18 and 44 years diagnosed by angiography were enrolled retrospectively. They were divided into two groups according to age: young CAD was defined as patients aged between 36 and 44 years, and very young CAD was defined as patients aged between 18 and 35 years. Demographic and clinical characteristics of the patients were collected.
In total, 9286 patients were included in the final database. Most were assigned to the young CAD group (86.5%), and 1250 (13.5%) had very young CAD. Most demographic and clinical characteristics of the young and very young patients with CAD differed significantly. The proportion of patients with CAD in the total population increased with age, whereas the incidence of AMI showed a decreasing trend. A previous percutaneous coronary intervention (PCI) was negatively associated with AMI. Dyslipidemia, current smoking, and hyperhomocysteinemia were positively associated with AMI in the overall and young population with CAD.
The clinical profiles and factors associated with AMI in CAD patients of different ages were significantly different. Lifestyle-related factors were significantly associated with AMI in young patients with CAD.
本研究旨在比较年轻和极年轻冠心病（CAD）患者的特征，并根据年龄探讨与急性心肌梗死（AMI）相关的因素。
回顾性纳入经血管造影诊断为年龄在 18 至 44 岁的年轻 CAD 患者。根据年龄将其分为两组：年轻 CAD 定义为年龄在 36 至 44 岁的患者，极年轻 CAD 定义为年龄在 18 至 35 岁的患者。收集患者的人口统计学和临床特征。
共纳入 9286 例患者，最终数据库中大多数患者被分配到年轻 CAD 组（86.5%），1250 例（13.5%）为极年轻 CAD。年轻和极年轻 CAD 患者的大多数人口统计学和临床特征差异显著。随着年龄的增长，CAD 在总人口中的比例增加，而 AMI 的发生率呈下降趋势。既往经皮冠状动脉介入治疗（PCI）与 AMI 呈负相关。血脂异常、当前吸烟和高同型半胱氨酸血症与总体 CAD 患者和年轻 CAD 患者的 AMI 呈正相关。
不同年龄 CAD 患者的临床特征和与 AMI 相关的因素存在显著差异。生活方式相关因素与年轻 CAD 患者的 AMI 显著相关。
