Synthesis of a natural quinoline alkaloid isolated from the deep-sea-derived fungus and its potential as a therapeutic for Parkinson's disease.

2-(Quinoline-8-carboxamido)benzoic acid (2-QBA; ) is a natural quinoline alkaloid isolated from the deep-sea-derived fungus sp. SCSIO06786. Alkaloid was synthesized by an amidation reaction of 8-quinolinecaroxylic acid with methyl anthranilate, followed by hydrolysis. The neuroprotective properties of 1 were evaluated using a Parkinson's disease model, which revealed that significantly ameliorated 1-methyl-4-phenylpyridinium (MPP)-induced dopaminergic neurodegeneration in a dose-dependent manner. MPP-induced behavioral defects in worms, including impaired locomotion and basal slowing ability, were restored by treatment with . We further demonstrated that treatment with modulates the formation of neurotoxic α-synuclein oligomers by suppressing α-synuclein expressions and enhancing proteasome activity. These results suggest that is a promising therapeutic candidate for the treatment of Parkinson's disease.