非转移性乳腺癌女性患者血清皮质醇、AGEs 相关 s100A8/A9 水平与自报癌症相关困扰的关系。
Relationships Between Serum Cortisol, RAGE-Associated s100A8/A9 Levels, and Self-Reported Cancer-Related Distress in Women With Nonmetastatic Breast Cancer.
机构信息
From the Department of Medical Social Science (Taub), Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Microbiology and Immunology (Diaz, Blomberg), University of Miami Miller School of Medicine, Miami, Florida; Department of Psychiatry and Behavioral Sciences (Jutagir), Memorial Sloan Kettering Cancer Center, New York, New York; Department of Psychiatry and Behavioral Sciences (Fisher), Duke University School of Medicine, Durham, North Carolina; Department of Health Outcomes and Behavior (Gudenkauf), Moffitt Cancer Center, Tampa, Florida; Department of Oncology and Medicine (Lippman), Georgetown Lombardi Comprehensive Cancer Center; Oncology Academic Department (Hudson), Georgetown University School of Medicine, Washington, DC; Department of Psychology (Antoni), University of Miami, Coral Gables, Florida.
出版信息
Psychosom Med. 2022 Sep 1;84(7):803-807. doi: 10.1097/PSY.0000000000001109. Epub 2022 Jul 28.
OBJECTIVE
Elevated inflammation and psychological distress in patients with breast cancer (BCa) have been related to poorer health outcomes. Regulation of the hypothalamic-pituitary-adrenal axis and signaling of the receptor for advanced glycation end products (RAGE) are important in the inflammatory response and have been associated with increased stress and poorer health outcomes in patients with cancer. This study examined relationships among circulating cortisol, a measure of hypothalamic-pituitary-adrenal axis activity and physiological stress; s100A8/A9, a RAGE ligand and emerging cancer-related biological measure; and self-reported cancer-related distress.
METHODS
Patients with BCa ( N = 183, stages 0-IIIb) were recruited 2 to 10 weeks after surgery but before receiving adjuvant therapies. Participants provided blood samples, from which serum cortisol and s100A8/A9 levels were determined, and completed a psychosocial questionnaire. Regression analyses, adjusting for age, cancer stage, time since surgery, race, and menopausal status, were conducted examining the relationships between cortisol, s100A8/A9, and cancer-related distress (Impact of Event Scale [IES]-Revised).
RESULTS
Cortisol and s100A8/A9 levels were positively related ( β = 0.218, t (112) = 2.332, p = .021), although the overall model was not significant. Cortisol levels were also positively associated with IES-Intrusions ( β = 0.192, t (163) = 2.659, p = .009) and IES-Hyperarousal subscale scores ( β = 0.171, t (163) = 2.304, p = .022).
CONCLUSIONS
Patients with higher cortisol levels also reported higher s100A8/A9 levels and more cancer-related distress. The relationship between cortisol and s100A8/A9 supports a link between the stress response and proinflammatory physiological processes known to predict a greater metastatic risk in BCa. Stress processes implicated in cancer biology are complex, and replication and extension of these initial findings are important.
目的
乳腺癌（BCa）患者的炎症和心理困扰与较差的健康结果有关。下丘脑-垂体-肾上腺轴的调节和晚期糖基化终产物（RAGE）受体的信号转导在炎症反应中很重要，并且与癌症患者的压力增加和健康结果较差有关。本研究检查了循环皮质醇（下丘脑-垂体-肾上腺轴活性和生理应激的一种测量方法）、s100A8/A9（RAGE 配体和新兴的癌症相关生物测量方法）和自我报告的癌症相关困扰之间的关系。
方法
招募了 183 名 BCa 患者（0-IIIb 期），他们在手术后 2-10 周内但在接受辅助治疗之前接受了手术。参与者提供了血液样本，从中测定了血清皮质醇和 s100A8/A9 水平，并完成了一份心理社会问卷。进行了回归分析，调整了年龄、癌症分期、手术时间、种族和绝经状态，以检查皮质醇、s100A8/A9 和癌症相关困扰（事件影响量表[IES]-修订版）之间的关系。
结果
皮质醇和 s100A8/A9 水平呈正相关（β=0.218，t（112）=2.332，p=0.021），尽管总体模型不显著。皮质醇水平也与 IES-侵入（β=0.192，t（163）=2.659，p=0.009）和 IES-过度警觉亚量表得分（β=0.171，t（163）=2.304，p=0.022）呈正相关。
结论
皮质醇水平较高的患者也报告了更高的 s100A8/A9 水平和更多的癌症相关困扰。皮质醇与 s100A8/A9 之间的关系支持应激反应与已知预测 BCa 更高转移风险的促炎生理过程之间的联系。涉及癌症生物学的应激过程很复杂，复制和扩展这些初步发现很重要。
Zotero 插件