FGFRL1 和 FGF 基因与身高、高血压和骨质疏松症有关。
FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis.
机构信息
Department of Medical Sciences, Graduate School, Soonchunhyang University, Asan, Chungnam, Republic of Korea.
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Chungnam, Republic of Korea.
出版信息
PLoS One. 2022 Aug 18;17(8):e0273237. doi: 10.1371/journal.pone.0273237. eCollection 2022.
Hypertension and osteoporosis are two major disorders, which interact with each other. Specific genetic signals involving the fibroblast growth factor receptor-like 1 (FGFRL1) gene are related to high blood pressure and bone growth in giraffes. FGFRL1 is associated with cardiovascular system and bone formation. We performed an association study to investigate the role of FGFRL1 in hypertension, osteoporosis, and height determination in humans. In addition, we identified three kinds of phenotypes in fibroblast growth factor (FGF) genes and examined their association with the FGFRL1 gene. We identified 42 SNPs in the FGFRL1 gene associated with each trait. We then analyzed the potential functional annotation of each SNP. The FGFRL1 gene was found to be associated with height, hypertension, and osteoporosis, consistent with the results of a previous study. In addition, the FGF2, FGF4, FGF10, FGF18, and FGF22 genes were found to interact with the FGFRL1 gene. Our study suggests that both FGFRL1 and FGFRL1-related genes may determine the height and the prevalence of osteoporosis and hypertension in the Korean population.
高血压和骨质疏松症是两种主要的疾病，它们相互作用。涉及成纤维细胞生长因子受体样 1 (FGFRL1) 基因的特定遗传信号与长颈鹿的高血压和骨骼生长有关。FGFRL1 与心血管系统和骨骼形成有关。我们进行了一项关联研究，以调查 FGFRL1 在人类高血压、骨质疏松症和身高决定中的作用。此外，我们还鉴定了三种成纤维细胞生长因子 (FGF) 基因中的表型，并研究了它们与 FGFRL1 基因的关联。我们在 FGFRL1 基因中鉴定出 42 个与每个特征相关的 SNP。然后，我们分析了每个 SNP 的潜在功能注释。发现 FGFRL1 基因与身高、高血压和骨质疏松症有关，与之前的研究结果一致。此外，还发现 FGF2、FGF4、FGF10、FGF18 和 FGF22 基因与 FGFRL1 基因相互作用。我们的研究表明，FGFRL1 和与 FGFRL1 相关的基因都可能决定韩国人群的身高和骨质疏松症和高血压的患病率。
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