Huang Qi-Tang, Li Yan-Li
Department of Pathological Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China.
Department of Pathological Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China;Department of Pathology, Anhui Medical University First Hospital, Hefei 230022, Anhui Province, China. E-mail：
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Aug;30(4):1277-1280. doi: 10.19746/j.cnki.issn.1009-2137.2022.04.049.
Iron metabolism is the process of absorption, transport, storage and conversion and excretion of the essential trace element iron in living organisms. Normal iron metabolism tightly regulates iron content at the systemic and cellular levels through a variety of related proteins to prevent excessive free radicals from being generated during the iron cycle that can damage the body. Various abnormalities in iron metabolism are found in a variety of lymphohaematopoietic tumours and an insidious link between iron metabolism and tumour development has been revealed. Serum ferritin levels and abnormalities of iron transport proteins, transferrin and their receptors can be used as prognostic indicators for lymphohematopoietic tumours and have opened up new directions of diagnosis and treatment, with a large number of novel drugs targeting tumours emerging to date. This article briefly describes the normal iron metabolism process and highlights the progress of research on abnormal iron metabolism in lymphohematopoietic tumors at the systemic and cellular levels.
铁代谢是生物体中必需微量元素铁的吸收、运输、储存、转化及排泄过程。正常的铁代谢通过多种相关蛋白在全身和细胞水平严格调控铁含量，以防止铁循环过程中产生过多可损害机体的自由基。在多种淋巴造血系统肿瘤中发现了铁代谢的各种异常情况，并且揭示了铁代谢与肿瘤发展之间存在潜在联系。血清铁蛋白水平以及铁转运蛋白、转铁蛋白及其受体的异常可作为淋巴造血系统肿瘤的预后指标，为诊断和治疗开辟了新方向，迄今已有大量靶向肿瘤的新型药物问世。本文简要描述了正常铁代谢过程，并着重介绍了在全身和细胞水平上淋巴造血系统肿瘤中铁代谢异常的研究进展。
