Li Xiao-Na, Qu Wen
Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Aug;30(4):1296-1300. doi: 10.19746/j.cnki.issn.1009-2137.2022.04.053.
The gut microbiota is an important part of the human body, and it's also the largest genome in the human body. Recent studies on the gut microbiota have found that it plays an important role in human immune diseases. In recent years, the methods of sequencing gut microbiota has teen improved, thus dysregulation of the gut microbiota is found in many immune diseases, and the most widely studied mechanism is the short-chain fatty acids (SCFA), which is a metabolite of gut microbiota. The role of short-chain fatty acids in intestinal barrier, IgA immunity, dendritic cells and regulatory T cells has become increasingly clear. The mechanisms of short-chain fatty acids in regulating immunity and its role in the pathogenesis of immune thrombocytopenia were covered in this review, so as to provide a new idea for the treatment of immune thrombocytopenia in the future.
肠道微生物群是人体的重要组成部分，也是人体中最大的基因组。近年来对肠道微生物群的研究发现，它在人类免疫疾病中发挥着重要作用。近年来，肠道微生物群的测序方法不断改进，因此在许多免疫疾病中都发现了肠道微生物群的失调，而研究最广泛的机制是短链脂肪酸（SCFA），它是肠道微生物群的一种代谢产物。短链脂肪酸在肠道屏障、IgA免疫、树突状细胞和调节性T细胞中的作用越来越清晰。本文综述了短链脂肪酸调节免疫的机制及其在免疫性血小板减少症发病机制中的作用，以期为未来免疫性血小板减少症的治疗提供新思路。
