Peters M, Walling D M, Waggoner J, Avigan M I, Sjogren M, Hoofnagle J H
J Hepatol. 1986;3 Suppl 2:S283-9. doi: 10.1016/s0168-8278(86)80133-7.
The effect of prolonged alpha-interferon therapy on immune function was studied in patients with chronic type B hepatitis. These patients with chronic type B hepatitis have been shown to have a defect in their in vitro response to human recombinant alpha-interferon. This defect consists of a failure to augment pokeweed mitogen-stimulated immunoglobulin production at low concentrations of interferon and an increased susceptibility to the suppressive effects of interferon. After 2 weeks therapy with interferon, immunoglobulin production was further suppressed. However, after 4 months of therapy with interferon, pokeweed mitogen-stimulated immunoglobulin production partially returned towards the pretreatment values. Antibody to hepatitis B core antigen was less affected by interferon therapy. This altered response to interferon was not specific as it was seen in some patients with other forms of liver disease. The suppression of B cell differentiation appears to be separate from its antiviral and antiproliferative effects.
对慢性乙型肝炎患者进行了长期α干扰素治疗对免疫功能影响的研究。这些慢性乙型肝炎患者已被证明对人重组α干扰素有体外反应缺陷。该缺陷包括在低浓度干扰素时不能增强商陆有丝分裂原刺激的免疫球蛋白产生，以及对干扰素抑制作用的敏感性增加。干扰素治疗2周后，免疫球蛋白产生进一步受到抑制。然而，干扰素治疗4个月后，商陆有丝分裂原刺激的免疫球蛋白产生部分恢复到治疗前水平。乙型肝炎核心抗原抗体受干扰素治疗的影响较小。这种对干扰素的反应改变并非特异性的，因为在一些其他形式肝病患者中也可见到。B细胞分化的抑制似乎与其抗病毒和抗增殖作用无关。
