不仅仅是口服暴露前预防:探索东北走廊中不同种族的男男性行为者对直肠冲洗、可溶解植入物、可移除植入物和注射 HIV 预防方法的兴趣。

More than just oral PrEP: exploring interest in rectal douche, dissolvable implant, removable implant and injection HIV prevention approaches among racially diverse men who have sex with men in the Northeast Corridor.

机构信息

College of Medicine, University of Central Florida, Orlando, Florida, USA

School of Social and Behavioral Sciences, Stockton University, Galloway, New Jersey, USA.

出版信息

BMJ Open. 2022 Aug 18;12(8):e063474. doi: 10.1136/bmjopen-2022-063474.

Abstract

OBJECTIVES

HIV scholars and practitioners have worked to expand strategies for prevention among marginalised populations who are disproportionately impacted by the epidemic, such as racial minority men who have sex with men (MSM). Given this urgency, the objective of this study was to assess interest in biomedical prevention strategies.

METHODS

This exploratory and cross-sectional study investigated interest in four biomedical prevention tools-rectal douche, dissolvable implant, removable implant and injection-among a racially diverse sample of MSM from the Northeast Corridor region between Philadelphia and Trenton. Data were collected as part of screening for , a couples-based HIV prevention intervention for Latino MSM and their partners.

RESULTS

A total of 381 individuals participated in the screener and provided information about their interest in bio tools. Approximately 26% of participants identified as black, 28% as white and 42% as 'other' or multiracial; 49% identified as Latino. Majority (54%) reported some form of child sexual abuse. Of the participants who reported being in a primary relationship (n=217), two-thirds reported unprotected anal sex within that relationship over the past 90 days (n=138, 64%) and approximately half (n=117, 54%) reported unprotected anal sex outside of the relationship in this period. Majority of participants reported interest in all bio tools assessed, including dissolvable implants (60%), removable implants (64%), rectal douching (79%) and injection (79%). Although interest in bio tools was broadly unassociated with demographics and sexual risk behaviours, analyses revealed significant associations between reports of child sexual abuse and interest in implant and injection methods.

CONCLUSIONS

The authors recommend investing in these prevention methods, particularly rectal douching and injection, as a means of preventing HIV among racial minority MSM. Given the interest in biomedical prevention tools, future studies should explore potential strategies for adherence.

摘要

目的

艾滋病毒学者和从业者一直在努力扩大针对受疫情影响最大的边缘化人群(如与男性发生性关系的少数族裔男性[MSM])的预防策略。鉴于这种紧迫性,本研究的目的是评估对生物医学预防策略的兴趣。

方法

这项探索性和横断面研究调查了对来自费城和特伦顿之间东北走廊地区的种族多样化 MSM 样本中四种生物医学预防工具的兴趣 - 直肠冲洗、可溶解植入物、可移动植入物和注射。数据是作为基于伴侣的艾滋病毒预防干预措施的一部分收集的,用于拉丁裔 MSM 及其伴侣。

结果

共有 381 人参加了筛查,并提供了他们对生物工具的兴趣信息。大约 26%的参与者认定为黑人,28%为白人,42%为“其他”或多种族裔;49%认定为拉丁裔。大多数(54%)报告了某种形式的儿童性虐待。在报告处于主要关系的参与者中(n=217),三分之二的人在过去 90 天内报告在该关系中发生了无保护的肛交(n=138,64%),大约一半(n=117,54%)在该期间在该关系之外发生了无保护的肛交。大多数参与者对评估的所有生物工具都表示感兴趣,包括可溶解植入物(60%)、可移动植入物(64%)、直肠冲洗(79%)和注射(79%)。尽管对生物工具的兴趣与人口统计学和性风险行为广泛无关,但分析显示,儿童性虐待报告与对植入物和注射方法的兴趣之间存在显著关联。

结论

作者建议投资于这些预防方法,特别是直肠冲洗和注射,作为预防少数族裔 MSM 艾滋病毒的一种手段。鉴于对生物医学预防工具的兴趣,未来的研究应探讨潜在的依从性策略。

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