Hegde P, Gunishetty V, Shetty V, Shetty U, Abraham S, Bajjuri S
Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Mangaluru, Karnataka, India.
Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Mangaluru, Karnataka, India.
Int J Oral Maxillofac Surg. 2023 Apr;52(4):409-412. doi: 10.1016/j.ijom.2022.07.010. Epub 2022 Aug 15.
The objective of this study was to evaluate the accuracy and feasibility of intraoperative frozen section analysis of samples harvested with a trephine drill from the bone resection margins to identify malignancy. Thirty-five patients who were diagnosed with locally advanced oral squamous cell carcinoma involving the mandible were included in this study. After tumour resection, bone samples were collected from the resection margin of the specimen using a trephine drill. Sampling yielded a cylindrical specimen of bony tissue that included both cortical and cancellous areas. A second sample was obtained from the area where bone invasion was evident; this was used as a positive control. Frozen section analysis was performed intraoperatively to check for malignancy. The sensitivity of this technique was found to be 81.8%, with specificity of 87.5%, a positive predictive value of 75%, negative predictive value of 91.3%, and accuracy of 85.7% when compared to standard histopathology as the gold standard. In conclusion, the evaluation of bone margins using the trephine drill technique and frozen section analysis proved to be fast and reliable.
本研究的目的是评估使用环钻从骨切除边缘采集样本进行术中冰冻切片分析以识别恶性肿瘤的准确性和可行性。本研究纳入了35例被诊断为累及下颌骨的局部晚期口腔鳞状细胞癌患者。肿瘤切除后，使用环钻从标本的切除边缘采集骨样本。采样得到一个包含皮质和松质区域的圆柱形骨组织标本。从骨侵袭明显的区域获取第二个样本；将其用作阳性对照。术中进行冰冻切片分析以检查是否存在恶性肿瘤。与作为金标准的标准组织病理学相比，该技术的敏感性为81.8%，特异性为87.5%，阳性预测值为75%，阴性预测值为91.3%，准确性为85.7%。总之，使用环钻技术和冰冻切片分析评估骨边缘被证明是快速且可靠的。
