Zheng Y J, Hu G P, Lu Y J, Li Y, Dong K L, Wang Kailin
Department of Epidemiology, Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory for Health Technology Assessment, National Commission of Health/School of Public Health, Fudan University, Shanghai 200032, China.
Department of Clinical Laboratory, Anqing Hospital Affiliated in Anhui Medical University/Anqing Municipal Hospital, Anqing 246003, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Aug 10;43(8):1326-1332. doi: 10.3760/cma.j.cn112338-20220504-00376.
Recently, the cases of acute hepatitis of unknown etiology (AHUE) in children worldwide have been increasing continuously and rapidly, involving more than 396 cases in 26 countries, and global public health actions, including surveillance, health alerts, research, are being implemented. AHUE mainly affects immunocompetent children with typical acute hepatitis, which can be severe and require liver transplantation. There are few systematic studies at present; the risk factors are unknown, the etiology remains to be established, and the clinical features and pathogenesis remain elucidated. It is urgent to strengthen the monitoring and research of AHUE cases.
最近，全球范围内儿童不明病因急性肝炎（AHUE）病例持续快速增加，涉及26个国家的396例以上，目前正在采取包括监测、健康警报、研究在内的全球公共卫生行动。AHUE主要影响具有典型急性肝炎症状的免疫功能正常儿童，病情可能严重，需要进行肝移植。目前系统研究较少；危险因素不明，病因有待确定，临床特征和发病机制仍有待阐明。加强对AHUE病例的监测和研究迫在眉睫。
