Department of Neurology, The 904th Hospital of PLA, Medical School of Anhui Medical University, Wuxi, China.
State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Sci Rep. 2022 Aug 18;12(1):14099. doi: 10.1038/s41598-022-18491-3.
It is unclear whether the face perceptual processing, especially the perceptual computation in early stages of processing faces, impaired in young patients with major depressive disorder (MDD). In this study, the face perception was investigated by analyzing the early ERP components in response to upright and inverted faces versus objects. Across all conditions, both the P1 and the N170 components were similar in MDD patients versus in the controls, regardless of latencies or amplitudes. Faces elicited larger N170 than objects (N170 face effect) and inverted faces elicited higher and delayed N170 (N170 inversion effect); however, none of these effects were modulated by depression. These findings suggest that there is intact perceptual mechanism of processing faces in young MDD patients, relying primarily on global/configural information versus non-face objects.
目前尚不清楚年轻的重度抑郁症（MDD）患者是否存在面部知觉处理障碍，尤其是在处理面部的早期阶段。在这项研究中，我们通过分析对直立和倒置的面部与物体的早期 ERP 成分来研究面部知觉。在所有条件下，MDD 患者与对照组的 P1 和 N170 成分相似，无论是潜伏期还是振幅。与物体相比，面部引发更大的 N170（N170 面部效应），而倒置的面部引发更高和延迟的 N170（N170 倒置效应）；然而，这些效应都不受抑郁的调节。这些发现表明，年轻的 MDD 患者存在面部知觉处理的完整知觉机制，主要依赖于整体/形态信息而非非面部物体。
