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锝-乙胺丁醇单光子发射计算机断层扫描/计算机断层扫描在脊柱结核中的显像

Tc-Ethambutol Scintigraphy with Single-Photon Emission Computed Tomography/Computed Tomography in Vertebral Tuberculosis.

作者信息

Khurana Aditi, Damle Nishikant, Kumar Rakesh, Ranjan Piyush, Sikdar Sunit, Arora Geetanjali

机构信息

Department of Nuclear Medicine, AIIMS, New Delhi, India.

Department of Medicine, AIIMS, New Delhi, India.

出版信息

Indian J Nucl Med. 2022 Apr-Jun;37(2):169-171. doi: 10.4103/ijnm.ijnm_162_21. Epub 2022 Jul 8.

Abstract

Vertebral tuberculosis (TB) is a common form of extrapulmonary TB. Here, the slow-growing Mycobacterium bacillus reaches the disc space through the hematogenous route and leads to various complications. Radiological imaging and histopathology have been the mainstay of diagnosis, but radionuclide imaging techniques using radiolabeled antitubercular drugs have rarely found space in the clinical domain. Here, we present a case of vertebral TB, where a technetium-labeled antitubercular drug, ethambutol, was synthesized and used for imaging the bacteria . Thus, we demonstrate a rarely used potentially specific agent for tuberculous-infection imaging, which can be produced in-house, and provides rapid results.

摘要

脊柱结核是肺外结核的一种常见形式。在此,生长缓慢的结核分枝杆菌通过血行途径到达椎间盘间隙并引发各种并发症。放射影像学和组织病理学一直是诊断的主要手段,但使用放射性标记抗结核药物的放射性核素成像技术在临床领域很少有应用。在此,我们报告一例脊柱结核病例,其中合成了一种锝标记的抗结核药物乙胺丁醇并用于对细菌进行成像。因此,我们展示了一种很少使用的、潜在特异性的结核感染成像剂,它可以在内部制备,并能快速得出结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375a/9380806/150b10f6b46e/IJNM-37-169-g001.jpg

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