Fueyo A, Esteban M M, Marín B, Rojo-Ortega J M
J Lab Clin Med. 1987 Jul;110(1):106-12.
Malignant hypertension was induced in Wistar rats of both sexes by complete aortic ligature just above the origin of the left renal artery. An acute and a late phase of hypertension, 4 days and 28 days after the aortic ligature respectively, were defined to study the relationship between the severity of hypertension and injury of the small arteries and myocardial necrosis. The most frequent finding in the heart was the presence of right ventricular infarction. In acute-phase hypertension most of the animals showed acute infarction of the right ventricle, but only focal left ventricular infarction was found. Lesions in the large coronary arteries were not observed. However, the small arteries and arterioles of the right ventricle presented fibrinoid necrosis lesions. In late-phase hypertension, the intramyocardial small vessels showed proliferative endarteritis and fibrinoid necrosis lesions, but this time they appeared in both ventricles. The severity of the myocardial infarcts and the percentage of small arteries and arterioles injured in the right ventricle were significantly higher than in the left ventricle despite the maintenance of blood pressure almost to the same level. No changes in the right ventricular pressure were observed in either phase. These observations suggest that in malignant renovascular hypertension the intramyocardial arteriolar lesions appear to be an important factor in the production and the severity of myocardial infarcts with predominance in the right ventricle.
通过在左肾动脉起始部上方完全结扎主动脉，诱导雌雄Wistar大鼠发生恶性高血压。分别在主动脉结扎后4天和28天定义高血压的急性期和晚期，以研究高血压严重程度与小动脉损伤及心肌坏死之间的关系。心脏最常见的表现是右心室梗死。在急性期高血压中，大多数动物表现为右心室急性梗死，但仅发现局灶性左心室梗死。未观察到大冠状动脉病变。然而，右心室的小动脉和小动脉呈现纤维蛋白样坏死病变。在晚期高血压中，心肌内小血管表现为增生性动脉内膜炎和纤维蛋白样坏死病变，但此时它们出现在两个心室。尽管血压几乎维持在相同水平，但右心室心肌梗死的严重程度以及小动脉和小动脉受损的百分比明显高于左心室。在两个阶段均未观察到右心室压力变化。这些观察结果表明，在恶性肾血管性高血压中，心肌内小动脉病变似乎是心肌梗死发生和严重程度的一个重要因素，且以右心室为主。
