Kumboyono Kumboyono, Chomsy Indah N, Firdaus Dylan H, Setiawan Meddy, Wihastuti Titin A
School of Nursing, Faculty of Health Sciences, University of Brawijaya, Malang, Indonesia.
Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, Indonesia.
J Taibah Univ Med Sci. 2022 Jan 23;17(4):701-706. doi: 10.1016/j.jtumed.2021.12.003. eCollection 2022 Aug.
This study aims to determine the protective cardiovascular effect of aerobic exercise training by measuring cluster of differentiation 146 (CD146), circulating endothelial cell (CEC), and high-density lipoprotein-cholesterol (HDL-C) levels in adults.
This study was an experimental pre-post-test without a control group. Forty-five participants were divided into three groups based on aerobic exercise training intensity: low, moderate, and high. Whole blood samples were measured for HDL-C levels. In addition, CEC was isolated from Peripheral Blood Mononuclear Cells (PBMC) samples, then identified by CD146 marker using flow cytometry.
CEC percentage and HDL-C increase after aerobic exercise training. There was a significant difference in CEC percentage between the intensity groups. However, there was no difference in HDL-C levels.
Aerobic exercise training can protect cardiovascular health by stimulating CEC mobilization, identified by CD146. In addition, an HDL-C level increase also contributes to cardiovascular protection by decreasing inflammation levels, inhibiting low-density lipoprotein-cholesterol oxidation, improving endothelial regeneration capabilities, and lowering blood glucose.
本研究旨在通过测量成年人的分化簇146（CD146）、循环内皮细胞（CEC）和高密度脂蛋白胆固醇（HDL-C）水平，确定有氧运动训练对心血管的保护作用。
本研究是一项无对照组的实验前后测试。45名参与者根据有氧运动训练强度分为三组：低强度、中等强度和高强度。测量全血样本中的HDL-C水平。此外，从外周血单个核细胞（PBMC）样本中分离出CEC，然后使用流式细胞术通过CD146标记物进行鉴定。
有氧运动训练后CEC百分比和HDL-C升高。强度组之间CEC百分比存在显著差异。然而，HDL-C水平没有差异。
有氧运动训练可通过刺激由CD146鉴定的CEC动员来保护心血管健康。此外，HDL-C水平升高还通过降低炎症水平、抑制低密度脂蛋白胆固醇氧化、改善内皮再生能力和降低血糖来促进心血管保护。
