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脓疱萎缩性小腿皮炎:超出头皮毛发范围的瘢痕性脱发

Dermatitis Cruris Pustulosa et Atrophicans: Scarring Alopecia Beyond Scalp Hair.

作者信息

João Ana Luísa, Cunha Nélia, Pinheiro Rita Ramos, Lencastre André

机构信息

Dermatology Department, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Dermatology Department, Hospital da Luz, Lisbon, Portugal.

出版信息

Skin Appendage Disord. 2022 Jul;8(4):280-286. doi: 10.1159/000521267. Epub 2022 Jan 19.

Abstract

Dermatitis Cruris Pustulosa et Atrophicans (DCPA) was first described in 1952 in Nigeria and is nowadays regarded as a type of chronic folliculitis of tropical areas. It is often limited to the lower limbs of young adults, mostly in the second to third decades, with a unique clinical picture characterized by chronicity, relentless progression, therapy refractoriness, and permanent cicatricial changes. Trauma, occlusion, and microorganism selection contribute for its etiopathogenesis, which is deemed multifactorial but still incompletely understood. Despite its conspicuous clinical features, awareness of DCPA is apparently low, hence probably overlooked. We herein summarize the current state of knowledge regarding this distinct entity, and further present the first report in a patient from Bangladesh, and concurrently the first in Europe. Paucity of data, and unraveled definite etiology and treatment, highlight the need for further studies.

摘要

脓疱萎缩性小腿皮炎(DCPA)于1952年在尼日利亚首次被描述,如今被视为热带地区的一种慢性毛囊炎。它通常局限于年轻成年人的下肢,多在二三十岁,具有独特的临床特征,表现为慢性、持续进展、治疗难治性和永久性瘢痕形成改变。创伤、闭塞和微生物选择在其发病机制中起作用,其发病机制被认为是多因素的,但仍未完全了解。尽管其临床特征明显,但对DCPA的认识显然较低,因此可能被忽视。我们在此总结了关于这一独特疾病的当前知识状态,并进一步报告了来自孟加拉国一名患者的首例病例,同时也是欧洲的首例病例。数据匮乏以及明确病因和治疗方法尚未阐明,凸显了进一步研究的必要性。

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