Department of Peripheral Vascular (Wound Repair), Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China.
Department of Urology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China.
Comput Math Methods Med. 2022 Aug 9;2022:7540020. doi: 10.1155/2022/7540020. eCollection 2022.
To evaluate the efficacy and application value of compound Phellodendron liquid (CPL) for negative-pressure wound therapy with instillation (NPWTi) in the treatment of diabetic foot ulcers by observing the improvement of diabetic foot ulcers.
Sixty patients with diabetic foot ulcers who met the inclusion criteria were admitted to the Department of Peripheral Blood Vessels (Wound Repair) of Chongqing Hospital of Traditional Chinese Medicine from August 2020 to August 2021. The random number table method divided it into the CPL NPWTi group and normal saline NPWTi group, with 30 cases in each group. The experimental group adopted FufangHuangbaiye for NPWTi, and the control group used normal saline for NPWTi. The treatment effect was evaluated by baseline index, wound healing observation index, inflammatory factor index, pain scores during dressing change, and the number of days in hospital.
After 10 days of treatment, the symptom integration, procalcitonin (PCT), and C reactive protein (CRP) of the CPL NPWTi group were significantly reduced compared with the normal saline NPWTi group, while there was no obvious difference between wound area and erythrocyte sedimentation rate (ESR). The wound area, symptom integral, PCT, ESR, and CRP of the CPL NPWTi group were significantly reduced compared with the normal saline NPWTi group after treatment for 20 days and 30 days. The positive proportion of bacterial culture in the CPL NPWTi group was significantly reduced compared with the normal saline NPWTi group after treatment for 10 days, 20 days, and 30 days. After treatment, the pain scores during dressing change and the number of days in hospital in normal saline NPWTi group were significantly lower than those in the CPL NPWTi group.
Compound Phellodendron liquid NPWTi therapy can improve diabetic foot ulcers, providing a safe and effective method for treating diabetic foot ulcers.
通过观察糖尿病足溃疡的改善情况，评价复方黄柏液用于灌注式负压伤口治疗（NPWTi）治疗糖尿病足溃疡的疗效及应用价值。
2020 年 8 月至 2021 年 8 月，将符合纳入标准的 60 例糖尿病足溃疡患者纳入重庆市中医院周围血管病科（创面修复科），采用随机数字表法分为复方黄柏液 NPWTi 组和生理盐水 NPWTi 组，每组 30 例。实验组采用复方黄柏液行 NPWTi，对照组采用生理盐水行 NPWTi。通过基线指标、创面愈合观察指标、炎症因子指标、换药疼痛评分和住院天数评估治疗效果。
治疗 10 天后，复方黄柏液 NPWTi 组的症状积分、降钙素原（PCT）和 C 反应蛋白（CRP）较生理盐水 NPWTi 组明显降低，而创面面积和红细胞沉降率（ESR）无明显差异。治疗 20 天和 30 天后，复方黄柏液 NPWTi 组的创面面积、症状积分、PCT、ESR 和 CRP 均较生理盐水 NPWTi 组明显降低。治疗 10 天、20 天和 30 天后，复方黄柏液 NPWTi 组的细菌培养阳性率明显低于生理盐水 NPWTi 组。治疗后，生理盐水 NPWTi 组的换药疼痛评分和住院天数均明显低于复方黄柏液 NPWTi 组。
复方黄柏液 NPWTi 治疗可改善糖尿病足溃疡，为治疗糖尿病足溃疡提供了一种安全有效的方法。
