Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Lucknow, Uttra Pradesh, India.
Rev Med Virol. 2023 Jan;33(1):e2383. doi: 10.1002/rmv.2383. Epub 2022 Aug 19.
Japanese encephalitis (JE) is a vector-borne neurotropic disease caused by Japanese encephalitis virus (JEV) associated with high mortality rate distributed from Eastern and Southern Asia to Northern Queensland (Australia). The challenges in early detection and lack of point-of-care biomarkers make it the most important Flavivirus causing encephalitis. There is no specific treatment for the disease, although vaccines are licenced. In this review, we focussed on point-of-care biomarkers as early detection tools and developing the effective therapeutic agents that could halt JE. We have also provided molecular details of JEV, disease progression, and its pathogenesis with recent findings which might bring insights to overcome the disease burden.
日本脑炎（JE）是一种由日本脑炎病毒（JEV）引起的虫媒神经毒病，分布于从东亚和南亚到澳大利亚昆士兰州北部。由于早期检测的困难和缺乏即时护理生物标志物，它成为最重要的引起脑炎的黄病毒。尽管有疫苗获得许可，但该疾病目前尚无特定的治疗方法。在本综述中，我们重点介绍了即时护理生物标志物作为早期检测工具，并开发了能够阻止 JE 发展的有效治疗药物。我们还提供了 JEV 的分子细节、疾病进展及其发病机制的最新发现，这些发现可能为克服疾病负担提供新的思路。
