Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Department of Otorhinolaryngology, Toyama Red Cross Hospital, Toyama, Japan.
Acta Otolaryngol. 2022 Jul-Aug;142(7-8):568-574. doi: 10.1080/00016489.2022.2108141. Epub 2022 Aug 19.
Delayed endolymphatic hydrops (DEH) is an inner ear disease that causes recurrent vertigo in the ipsilateral ear or fluctuating hearing in the contralateral ear due to endolymphatic hydrops secondary to preceding deafness. There are few reports of large, multicentre studies investigating the clinical-epidemiological characteristics of DEH.
This study aimed to clarify the characteristics of DEH in Japan.
Clinical data on 662 patients with DEH were analysed by nationwide, multicentre surveys conducted by the Peripheral Vestibular Disorders Research Group of Japan.
The proportion of ipsilateral DEH (IDEH) was slightly higher than that of contralateral DEH (CDEH) at 55.4%. The time delay between onset of precedent deafness and onset of DEH was significantly longer for CDEH than for IDEH. The most common cause of precedent deafness was a disease of unknown cause with onset in early childhood (33.1%). Epidemiological characteristics were not significantly different between CDEH with and without vertigo.
DEH appearing to be caused by viral labyrinthitis has a high rate of onset within 40 years of precedent deafness. Clinical and epidemiological characteristics of IDEH, CDEH with vertigo, and CDEH without vertigo were very similar.
The clinical-epidemiological characteristics of DEH in Japan were clarified.
迟发性内淋巴积水（DEH）是一种内耳疾病，由于先前耳聋继发的内淋巴积水，导致同侧耳反复发作眩晕或对侧耳听力波动。目前鲜有研究报告针对 DEH 的临床-流行病学特征进行大规模、多中心研究。
本研究旨在阐明日本 DEH 的特征。
通过日本周围前庭障碍研究小组进行的全国性多中心调查，对 662 例 DEH 患者的临床数据进行分析。
同侧 DEH（IDEH）的比例略高于对侧 DEH（CDEH），为 55.4%。CDEH 从先前耳聋到 DEH 发作的时间延迟明显长于 IDEH。先前耳聋最常见的原因是病因不明的疾病，发病于儿童早期（33.1%）。CDEH 有无眩晕与流行病学特征无显著差异。
似乎由病毒迷路炎引起的 DEH 发病时间距先前耳聋 40 年以内的比例较高。IDEH、有眩晕的 CDEH 和无眩晕的 CDEH 的临床和流行病学特征非常相似。
阐明了日本 DEH 的临床-流行病学特征。
