Department of Intensive Care, Gelre Hospitals, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands.
Expertise Center for Intensive Care Rehabilitation Apeldoorn (ExpIRA), Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands.
Intensive Care Med. 2022 Sep;48(9):1197-1205. doi: 10.1007/s00134-022-06841-8. Epub 2022 Aug 19.
Delirium during intensive care unit (ICU) stay may be related to premorbid mental illness. In addition, delirium during ICU stay may also negatively affect long-term health-related quality of life. The aim of our study was to investigate if delirium in the ICU is related to premorbid mental quality of life and affects long-term mental quality of life after ICU stay.
We performed a prospective cohort study in 1021 patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated mental and physical quality of life using the Short-form-12 before ICU admission, at hospital discharge, and 3, 6 and 12 months after hospital discharge. Mixed model and logistic regression models were used to analyze the data.
Patients who experienced a delirium during ICU stay reported a worse pre-admission mental quality of life than those without delirium (p < 0.001). Furthermore, patients who suffered from delirium during their ICU stay exhibited a significant decrease in mental quality of life over time relative to patients without delirium (p = 0.035).
In this large follow-up study, we demonstrated that ICU survivors who experienced a delirium during ICU stay reported a significantly worse pre-admission mental health-related quality of life and a significant decrease in mental health-related quality of life in the year after hospital discharge compared with patients without delirium.
重症监护病房（ICU）入住期间的谵妄可能与发病前的精神疾病有关。此外，ICU 入住期间的谵妄也可能对长期健康相关的生活质量产生负面影响。我们的研究目的是调查 ICU 中的谵妄是否与发病前的精神生活质量有关，并影响 ICU 入住后的长期精神生活质量。
我们对在一个内科-外科 ICU 住院超过 48 小时的 1021 名患者进行了前瞻性队列研究。我们在 ICU 入住前、出院时以及出院后 3、6 和 12 个月使用简短 12 项健康调查量表评估精神和身体生活质量。使用混合模型和逻辑回归模型分析数据。
在 ICU 入住期间经历谵妄的患者报告的 ICU 入住前精神生活质量比没有谵妄的患者差（p<0.001）。此外，与没有谵妄的患者相比，在 ICU 入住期间患有谵妄的患者在时间上的精神生活质量明显下降（p=0.035）。
在这项大型随访研究中，我们表明 ICU 幸存者在 ICU 入住期间经历谵妄的患者报告的 ICU 入住前心理健康相关生活质量明显较差，并且与没有谵妄的患者相比，在出院后一年的心理健康相关生活质量明显下降。
