Shahtaheri Rahill Sadat, Bayazidi Yahya, Davari Majid, Kebriaeezadeh Abbas, Yousefi Sepideh, Hezaveh Alireza Mahdavi, Sadeghi Abolfazl, aL Lami Ahmed Hayder Mohsin, Abbasian Hadi
Department of Pharmacoeconomics and Pharmaceutical administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of pharmacy and pharmaceutical science, Islamic adad university, Tehran, Iran.
Health Econ Rev. 2022 Aug 19;12(1):44. doi: 10.1186/s13561-022-00377-9.
The quality of health care has a significant impact on both patients and the health system in terms of long-term costs and health consequences. This study focuses on determining the long-term cost-effectiveness in quality of diabetes care in two different settings (private/public) using longitudinal patient-level data in Iran.
By extracting patients intermediate biomedical markers in under-treatment type 2 diabetes patients(T2DP) in a longitudinal retrospective study and by applying the localized UKPDS diabetes model, lifetime health outcomes including life expectancy, quality-adjusted Life expectancy (QALE) and direct medical costs of managing disease and related complications from a healthcare system perspective was predicted. Costs and utility decrements had derived on under-treatment T2DP from 7 private and 8 Public diabetes centers. We applied two steps sampling mehods to recruit the needed sample size (cluster and random sampling). To cope with first and second-order uncertainty, we used Monte-Carlo simulation and bootstrapping techniques. Both cost and utility variables were discounted by 3% in the base model.
In a 20-year time horizon, according to over 5 years of quality of care data, outcomes-driven in the private sector will be more effective and more costly (5.17 vs. 4.95 QALE and 15,385 vs. 8092). The incremental cost-effectiveness ratio (ICER) was $33,148.02 per QALE gained, which was higher than the national threshold.
Although quality of care in private diabetes centers resulted in a slight increase in the life expectancy in T2DM patients, it is associated with unfavorable costs, too. Private-sector in management of T2DM patients, compared with public (governmental) diabetic Centers, is unlikely to be cost-effective in Iran.
医疗保健质量在长期成本和健康后果方面对患者和医疗系统都有重大影响。本研究利用伊朗患者层面的纵向数据,重点确定两种不同环境(私立/公立)下糖尿病护理质量的长期成本效益。
在一项纵向回顾性研究中,提取未接受充分治疗的2型糖尿病患者(T2DP)的中间生物医学标志物,并应用本地化的英国前瞻性糖尿病研究(UKPDS)糖尿病模型,从医疗系统角度预测包括预期寿命、质量调整预期寿命(QALE)以及管理疾病和相关并发症的直接医疗成本等终身健康结果。成本和效用递减数据来自7家私立和8家公立糖尿病中心未接受充分治疗的T2DP患者。我们采用两步抽样方法(整群抽样和随机抽样)来招募所需样本量。为应对一阶和二阶不确定性,我们使用了蒙特卡洛模拟和自抽样法技术。在基础模型中,成本和效用变量均按3%进行贴现。
在20年的时间范围内,根据超过5年的护理质量数据,私立部门以结果为导向的护理将更有效但成本更高(QALE分别为5.17和4.95,成本分别为15385美元和8092美元)。每获得一个QALE的增量成本效益比(ICER)为33148.02美元,高于国家阈值。
虽然私立糖尿病中心的护理质量使2型糖尿病患者的预期寿命略有增加,但也伴随着不利的成本。在伊朗,与公立(政府)糖尿病中心相比,私立部门管理T2DM患者不太可能具有成本效益。