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本文引用的文献

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Comparison of Clinical Outcomes of Persons Living With HIV by Enrollment Status in Washington, DC: Evaluation of a Large Longitudinal HIV Cohort Study.华盛顿特区按入组状态比较 HIV 感染者的临床结局：一项大型纵向 HIV 队列研究的评估。
JMIR Public Health Surveill. 2020 Apr 15;6(2):e16061. doi: 10.2196/16061.
2
Sexually transmitted infections in persons living with HIV infection and estimated HIV transmission risk: trends over time from the DC Cohort.HIV 感染者中的性传播感染和估计的 HIV 传播风险：来自 DC 队列的随时间变化趋势。
Sex Transm Infect. 2020 Mar;96(2):89-95. doi: 10.1136/sextrans-2019-054216. Epub 2020 Jan 6.
3
HIV and sexually transmitted infections: reconciling estranged bedfellows in the U = U and PrEP era.艾滋病毒与性传播感染：在“U=U”和暴露前预防时代调和疏远的伙伴关系
J Int AIDS Soc. 2019 Aug;22 Suppl 6(Suppl Suppl 6):e25357. doi: 10.1002/jia2.25357.
4
Proportion of Incident Human Immunodeficiency Virus Cases Among Men Who Have Sex With Men Attributable to Gonorrhea and Chlamydia: A Modeling Analysis.男性性传播感染淋病和衣原体导致的人类免疫缺陷病毒新发感染病例比例：建模分析。
Sex Transm Dis. 2019 Jun;46(6):357-363. doi: 10.1097/OLQ.0000000000000980.
5
Earlier diagnoses and faster treatment of HIV in the District of Columbia: HIV surveillance analysis, 2006-2016.哥伦比亚特区艾滋病病毒的早期诊断与快速治疗：2006 - 2016年艾滋病病毒监测分析
AIDS Care. 2019 Dec;31(12):1476-1483. doi: 10.1080/09540121.2019.1595516. Epub 2019 Mar 22.
6
Defining Care Patterns and Outcomes Among Persons Living with HIV in Washington, DC: Linkage of Clinical Cohort and Surveillance Data.界定华盛顿特区艾滋病毒感染者的护理模式与结局：临床队列与监测数据的关联
JMIR Public Health Surveill. 2018 Mar 16;4(1):e23. doi: 10.2196/publichealth.9221.
7
Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort.哥伦比亚特区艾滋病毒感染者中的性传播感染及估计的艾滋病毒传播风险：来自华盛顿特区队列的数据
Open Forum Infect Dis. 2018 Jan 24;5(2):ofy017. doi: 10.1093/ofid/ofy017. eCollection 2018 Feb.
8
Antiretroviral Therapy for the Prevention of HIV-1 Transmission.抗逆转录病毒疗法预防HIV-1传播
N Engl J Med. 2016 Sep 1;375(9):830-9. doi: 10.1056/NEJMoa1600693. Epub 2016 Jul 18.
9
Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis.性传播疾病会增加艾滋病毒的传播：不再是一种假设。
Lancet. 1998;351 Suppl 3:5-7. doi: 10.1016/s0140-6736(98)90002-2.

随着时间的推移，艾滋病毒感染者的病毒学控制得到改善：缩小有和没有性传播感染人群之间的差距。

Improvements in Virologic Control Among PWH Over Time: Narrowing the Gap Between Those With and Without STIs.

机构信息

Division of Infectious Diseases, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Department of Epidemiology, George Washington University Milken Institute School of Public Health, Washington, DC, USA.

出版信息

AIDS Behav. 2023 Feb;27(2):673-677. doi: 10.1007/s10461-022-03802-6. Epub 2022 Aug 19.

DOI:10.1007/s10461-022-03802-6
PMID:35984609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10176187/
Abstract

Using the incidence of bacterial sexually transmitted infection (STI) as a surrogate for condomless sexual behavior, we assessed the association between STI and uncontrolled HIV replication among in-care persons with HIV (PWH) enrolled in a longitudinal HIV cohort study in the District of Columbia (the DC Cohort). Although STI occurrence initially correlated with higher HIV viral load (VL), this difference became more attenuated over time (2012-2016). This was true overall and among those with the greatest number of STIs [age 18-34, men who have sex with men (MSM)]. This likely reflects gains in population-wide virologic control through improved antiretroviral therapy and access to care, which helps mitigate the risk of HIV transmission.

摘要

以细菌性性传播感染 (STI) 的发生率作为无保护性行为的替代指标，我们评估了在哥伦比亚特区 (DC 队列) 纵向 HIV 队列研究中接受治疗的 HIV 感染者 (PWH) 中，STI 与 HIV 复制失控之间的关联。尽管 STI 的发生最初与较高的 HIV 病毒载量 (VL) 相关，但这种差异随着时间的推移 (2012-2016 年) 逐渐减弱。这在总体上以及在 STI 数量最多的人群中都是如此 [18-34 岁，男男性行为者 (MSM)]。这可能反映了通过改进抗逆转录病毒疗法和获得治疗，在人群中病毒学控制方面取得了进展，从而有助于降低 HIV 传播的风险。