School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Central University P.O., Hyderabad, 500 046, India.
Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, 560 012, India.
Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202207484. doi: 10.1002/anie.202207484. Epub 2022 Aug 19.
Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.
从药物分子中药物作用的分子药效团这一标记物出发，我们提出杂同化物（不同官能团之间的超分子合成子）在高生物利用度药物的设计和发现中起着类似的作用。杂同化物可以为新型药物提供更有效和经济的途径。
