Hospital for Small Animals, Royal (Dick) School of Veterinary Studies & the Roslin Institute, University of Edinburgh, Roslin, EH25 9RG, UK.
Hospital for Small Animals, Royal (Dick) School of Veterinary Studies & the Roslin Institute, University of Edinburgh, Roslin, EH25 9RG, UK.
J Vet Cardiol. 2022 Oct;43:41-54. doi: 10.1016/j.jvc.2022.07.002. Epub 2022 Aug 1.
Alternatives for out-of-clinic heart rate (HR) measurement are required to optimise the management of atrial fibrillation (AF) in dogs. Additionally, the presence of circadian variation (CV) in HR in pet dogs remains unknown. We aimed to identify the number and duration of spot-checks required for an accurate estimation of 24-hour HR in canine AF. Circadian variation in HR was examined in healthy dogs and dogs with AF, and spot-check-derived HR was compared with a CV-derived gold standard.
Ambulatory electrocardiogram data from healthy dogs and dogs with AF were retrospectively analysed. Heart rate was calculated from the entire recording and pre-defined periods (spot-checks) of one hour to 30 and 60 s in duration. Circadian variation in HR was determined by cosinor analysis. Bias and limits of agreement of means and median HR with mesor HR were determined by correlation and Bland-Altman analysis.
Circadian variation in HR was identified not only in 18/22 healthy dogs and 14/21 AF dogs but only on ambulatory electrocardiogram recordings. Four-hourly spot-checks provided the most accurate estimate of mesor HR in healthy dogs (bias of the median over 30 s 7.70, limits of agreement 7.48), whereas, in dogs with AF, four, six and eight-hourly spot-checks provided reliable estimates of mesor HR (bias within -1.29 and -29.5).
Four, six and eight-hourly HR spot-checks can estimate 24-hourly HR in dogs with AF. There was CV in HR in most healthy pet dogs and dogs with AF. Spot-check protocols cannot identify CV in HR.
需要替代门诊心率（HR）测量方法，以优化犬心房颤动（AF）的管理。此外，宠物犬 HR 的昼夜节律变化（CV）尚不清楚。我们的目的是确定准确估计犬 AF 24 小时 HR 所需的单次检查次数和持续时间。我们在健康犬和 AF 犬中检查了 HR 的 CV，并将单次检查得出的 HR 与 CV 衍生的金标准进行了比较。
回顾性分析了健康犬和 AF 犬的动态心电图数据。从整个记录和一个小时到 30 秒和 60 秒的预定义时间段（单次检查）计算 HR。通过余弦分析确定 HR 的 CV。通过相关性和 Bland-Altman 分析确定 HR 的均值和中位数与中值 HR 的偏倚和一致性界限。
不仅在 18/22 只健康犬和 14/21 只 AF 犬中，而且仅在动态心电图记录中发现了 HR 的 CV。在健康犬中，每 4 小时进行一次单次检查可提供最准确的中值 HR 估计（中位数的偏倚超过 30 秒为 7.70，一致性界限为 7.48），而在 AF 犬中，每 4、6 和 8 小时进行一次单次检查可提供可靠的中值 HR 估计（偏倚在-1.29 和-29.5 内）。
每 4、6 和 8 小时进行一次 HR 单次检查可估计 AF 犬的 24 小时 HR。大多数健康宠物犬和 AF 犬的 HR 存在 CV。单次检查方案无法识别 HR 的 CV。
