Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Departments of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Neuron. 2022 Sep 21;110(18):2916-2928. doi: 10.1016/j.neuron.2022.07.012. Epub 2022 Aug 18.
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.
神经母细胞瘤是导致儿童癌症死亡的主要原因。积累的数据表明,神经嵴衍生的交感肾上腺谱系的分化阻滞导致神经母细胞瘤的形成。这些细胞类型的发育阻滞解释了该疾病的许多生物学特征,包括其细胞异质性、突变谱、自发消退以及对诱导肿瘤细胞分化的药物的反应。在这篇综述中,我们提供了支持这样一种观点的证据,即阻滞的神经嵴衍生祖细胞导致神经母细胞瘤,并讨论了这一概念如何被用于该疾病的临床管理。