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Including APOL1 alleles and ancestry adjustments improve a genome-wide polygenic CKD score.

作者信息

Yu Zhi, Wuttke Matthias

机构信息

Program of Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Masschusetts, USA.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

出版信息

Kidney Int. 2022 Nov;102(5):954-955. doi: 10.1016/j.kint.2022.08.004. Epub 2022 Aug 17.

DOI:10.1016/j.kint.2022.08.004
PMID:35985372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10018747/
Abstract
摘要

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引用本文的文献

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本文引用的文献

1
Genome-wide polygenic score to predict chronic kidney disease across ancestries.基于全基因组的多基因风险评分预测不同种族人群的慢性肾脏病。
Nat Med. 2022 Jul;28(7):1412-1420. doi: 10.1038/s41591-022-01869-1. Epub 2022 Jun 16.
2
Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.慢性肾脏病中的遗传学：KDIGO（改善全球肾脏病预后组织）争议会议的结论。
Kidney Int. 2022 Jun;101(6):1126-1141. doi: 10.1016/j.kint.2022.03.019. Epub 2022 Apr 20.
3
Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.多基因风险评分与肾功能及其与循环蛋白质组学的关系，以及与新发肾脏疾病的关系。
J Am Soc Nephrol. 2021 Dec 1;32(12):3161-3173. doi: 10.1681/ASN.2020111599.
4
A catalog of genetic loci associated with kidney function from analyses of a million individuals.一项对 100 万人进行的分析显示，与肾功能相关的遗传基因座目录。
Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31.
5
The illusion of polygenic disease risk prediction.多基因疾病风险预测的幻象。
Genet Med. 2019 Aug;21(8):1705-1707. doi: 10.1038/s41436-018-0418-5. Epub 2019 Jan 12.
6
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.对 480,000 名成年人的冠心病的基因组风险预测：对一级预防的影响。
J Am Coll Cardiol. 2018 Oct 16;72(16):1883-1893. doi: 10.1016/j.jacc.2018.07.079.
7
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。
Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.
8
The personal and clinical utility of polygenic risk scores.多基因风险评分的个体和临床效用。
Nat Rev Genet. 2018 Sep;19(9):581-590. doi: 10.1038/s41576-018-0018-x.