Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.
Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.
Trends Pharmacol Sci. 2023 Jan;44(1):4-6. doi: 10.1016/j.tips.2022.08.001. Epub 2022 Aug 18.
The γ-aminobutyric acid transporter 1 (GAT1) is a transporter which clears the inhibitory neurotransmitter γ-aminobutyric acid (GABA) from the synaptic cleft. The paper by Motiwala et al. documents a structure of GAT1 in complex with the antiepileptic drug tiagabine. This study will enable structure-based docking of large chemical libraries for the discovery of novel antiepileptics.
γ-氨基丁酸转运蛋白 1（GAT1）是一种清除突触间隙抑制性神经递质γ-氨基丁酸（GABA）的转运蛋白。Motiwala 等人的论文描述了 GAT1 与抗癫痫药物噻加宾复合物的结构。这项研究将使基于结构的对接大型化学库成为可能，从而发现新的抗癫痫药物。
