Treatment of recurrent esthesioneuroblastoma with combined intra-arterial chemotherapy. A case report.

A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., vincristine i.v., procarbazine orally). 6 courses of chemotherapy were given with complete remission. The patient is free of disease and asymptomatic 24 months after treatment.