Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai, China.
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai, China.
Drug Test Anal. 2023 Jan;15(1):115-122. doi: 10.1002/dta.3359. Epub 2022 Sep 18.
The identification of new psychoactive substances (NPS) is an active and cutting-edge topic in forensic science. With the emergence of a large number of NPS, their timely identification to prevent spread can pose a challenge to clinical and forensic toxicology laboratories. Three emerging NPS had been identified in recently seized materials, including two synthetic cannabinoids [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobutyl)-1H-indazole-3-carboxamide (4F-AB-BUTINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-phenethyl-1H-indazole-3-carboxamide (AB-PHETINACA)] and a ketamine-like substance [2-(2-fluorophenyl)-2-(ethylamino) cyclohexan-1-one(2F-NENDCK)]. The three compounds were first identified by Fourier transform infrared spectrometry (FT-IR), gas chromatography-mass spectrometry (GC-MS), ultrahigh-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UHPLC-QTOF-MS), and nuclear magnetic resonance (NMR). These data may assist forensic analysts in analyzing the same substances or their homologous compounds.
新精神活性物质（NPS）的鉴定是法医学中一个活跃且前沿的课题。随着大量 NPS 的出现，及时鉴定这些物质以防止其传播，这对临床和法医毒理学实验室来说是一个挑战。在最近查获的物质中鉴定出了三种新兴的 NPS，包括两种合成大麻素[N-(1-氨基-3-甲基-1-氧代丁基)-1-(4-氟丁基)-1H-吲哚-3-甲酰胺（4F-AB-BUTINACA）和 N-(1-氨基-3-甲基-1-氧代丁基)-1-苯乙基-1H-吲哚-3-甲酰胺（AB-PHETINACA）]和一种类似氯胺酮的物质[2-(2-氟苯基)-2-(乙基氨基)环己酮（2F-NENDCK）]。这三种化合物最初是通过傅里叶变换红外光谱（FT-IR）、气相色谱-质谱联用（GC-MS）、超高效液相色谱-四极杆飞行时间质谱联用（UHPLC-QTOF-MS）和核磁共振（NMR）鉴定的。这些数据可能有助于法医分析人员分析相同物质或其同源化合物。
