端粒长度与心血管风险的关联：影响端粒和端粒酶活性的药物治疗。

Association Between Telomere Length and Cardiovascular Risk: Pharmacological Treatments Affecting Telomeres and Telomerase Activity.

机构信息

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Faculty of Stomatology, Pancevo, University Business Academy, 21000 Novi Sad, Serbia.

出版信息

Curr Vasc Pharmacol. 2022;20(6):465-474. doi: 10.2174/1570161120666220819164240.

DOI:10.2174/1570161120666220819164240

PMID:35986545

Abstract

Telomeres represent the ends of chromosomes, and they are composed of an extensive number of - TTAGGG nucleotide sequence repeats in humans. Telomeres prevent chromosome degradation, participate in stabilization, and regulate the DNA repair system. Inflammation and oxidative stress have been identified as important processes causing cardiovascular disease and accelerating telomere shortening rate. This review investigates the link between telomere length and pathological vascular conditions from experimental and human studies. Also, we discuss pharmacological treatments affecting telomeres and telomerase activity.

摘要

端粒代表染色体的末端，由人类大量的 - TTAGGG 核苷酸序列重复组成。端粒可防止染色体降解，参与稳定，并调节 DNA 修复系统。炎症和氧化应激被认为是导致心血管疾病和加速端粒缩短率的重要过程。本综述从实验和人体研究两方面探讨了端粒长度与病理性血管状况之间的联系。此外，我们还讨论了影响端粒和端粒酶活性的药物治疗方法。