阿托伐他汀治疗创伤后脑积水患者：病例报告。
Atorvastatin treatment in a patient with post-traumatic hydrocephalus: a case report.
机构信息
From the Department of Rehabilitation, the First Hospital of China Medical University, Shenyang, Liaoning, China.
出版信息
Brain Inj. 2022 Jul 29;36(9):1204-1206. doi: 10.1080/02699052.2022.2109750. Epub 2022 Aug 19.
OBJECTIVES
Clinical treatment of post-traumatic hydrocephalus (PTH) is limited to cerebrospinal fluid (CSF) extracranial shunting, and research on noninvasive treatment is still lacking. In a follow-up study of a patient with PTH, atorvastatin treatment was beneficial in controlling hydrocephalus and promoting neurological recovery.
METHOD
A 29-year-old male patient with traumatic brain injury (TBI) was found to have progressive hydrocephalus and presented with symptoms of decreased spontaneous speech and delayed functional recovery. We added oral treatment with 20 mg/day atorvastatin and followed up hydrocephalus with head CT every two months.
RESULTS
The span of the third ventricle decreased by 21%, Evan's index fell by 16%, and the Fugl-Meyer motor score was up from 17/100 to 56/100. The Montreal Cognitive Assessment score was modified from 15/30 to 23/30.
CONCLUSION
The use of atorvastatin in the patient may improve the imaging results and benefit the patient functionally.
目的
创伤后脑积水（PTH）的临床治疗仅限于脑室外引流，而无创治疗的研究仍相对缺乏。在对一名 PTH 患者的随访研究中，阿托伐他汀治疗有益于控制脑积水并促进神经功能恢复。
方法
一名 29 岁男性创伤性脑损伤（TBI）患者出现进行性脑积水，并表现出自发言语减少和功能恢复延迟的症状。我们增加了每天 20 毫克阿托伐他汀的口服治疗，并每两个月通过头部 CT 随访脑积水情况。
结果
第三脑室的跨度减少了 21%，Evan 指数下降了 16%，Fugl-Meyer 运动评分从 17/100 提高到 56/100。蒙特利尔认知评估评分从 15/30 提高到 23/30。
结论
阿托伐他汀在该患者中的使用可能改善了影像学结果，并对患者的功能有益。
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