Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, China.
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang Province, China.
Clin Transl Oncol. 2022 Dec;24(12):2342-2350. doi: 10.1007/s12094-022-02920-w. Epub 2022 Aug 20.
Long non-coding RNA (lncRNA) is a non-protein-coding RNA with a length of more than 200 nucleotides. Studies have shown that lncRNAs have vital impacts on various pathological processes and participate in the development of human diseases, usually through acting as competing endogenous RNAs to modulate miRNA expression and biological functions. lncRNA HOXA Cluster Antisense RNA 3 (HOXA-AS3) was a newly discovered lncRNA and has been demonstrated to be abnormally expressed in many diseases. Moreover, HOXA-AS3 expression was closely correlated with the clinicopathologic characteristics in cancer patients. In addition, HOXA-AS3 exhibited significant properties in regulating several biological processes, including cell proliferation, invasion, and migration. Furthermore, HOXA-AS3 has provided promising values in the diagnosis, prognosis, and therapeutic strategies of several diseases such as liver cancer, glioma, lung cancer, oral cancer, gastric cancer, and even atherosclerosis. In this review, we discuss the abnormal expression of HOXA-AS3 in several human disorders and some pathobiological processes and its clinical characteristics, followed by a summary of HOXA-AS3 functions, regulatory mechanisms, and clinical application potential.
长链非编码 RNA（lncRNA）是一种长度超过 200 个核苷酸的非蛋白编码 RNA。研究表明，lncRNAs 对各种病理过程具有重要影响，并参与人类疾病的发展，通常通过作为竞争性内源性 RNA 来调节 miRNA 的表达和生物学功能。HOXA 基因簇反义 RNA3（HOXA-AS3）是一种新发现的 lncRNA，已证明在许多疾病中异常表达。此外，HOXA-AS3 的表达与癌症患者的临床病理特征密切相关。此外，HOXA-AS3 在调节细胞增殖、侵袭和迁移等多种生物学过程中表现出显著的特性。此外，HOXA-AS3 在肝癌、神经胶质瘤、肺癌、口腔癌、胃癌甚至动脉粥样硬化等多种疾病的诊断、预后和治疗策略中提供了有希望的价值。在这篇综述中，我们讨论了 HOXA-AS3 在几种人类疾病中的异常表达及其在一些病理生物学过程中的临床特征，随后总结了 HOXA-AS3 的功能、调控机制及其临床应用潜力。
