Jeong Yejun, Kim Yongjae, Kim Wonhyun, Park Seoyeon, Shin Su-Jin, Park Eun Jung
Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Int J Surg Case Rep. 2022 Sep;98:107524. doi: 10.1016/j.ijscr.2022.107524. Epub 2022 Aug 17.
Introduction and importance: Colonic pseudo-obstruction (CPO) is characterized by massive colonic dilatation of the large intestine without mechanical obstruction. In this study, we report our surgical experience in treating refractory CPO with increased anal sphincter tone, suggested as type IV dyssynergia.
A 48-year-old man with intellectual disability, depression, heart failure, and end-stage renal disease presented with acute exacerbation of CPO. He had a history of chronic constipation and abdominal distension. Colonic dilatation and defecation difficulty persisted despite medication and repeated colonoscopic decompression. Anal manometry results indicated type IV dyssynergia with increased rectal pressure. Hartmann's operation was performed to resect the redundant megacolon and to avoid increased anal sphincter pressure during defecation. Hypoganglionosis was observed in the resected colon, which could worsen the chronic process of CPO.
Meticulous evaluation and careful management are required to treat CPO patients because the pathophysiology of CPO has not yet been clearly identified. Proper surgical treatment is needed for patients with refractory CPO.
CPO requires meticulous evaluation and careful management owing to the risk of bowel perforation. Precise evaluation to identify other factors affecting defecation problems accompanied by CPO is required to make appropriate treatment decisions.
引言与重要性:结肠假性梗阻(CPO)的特征是大肠出现巨大的结肠扩张但无机械性梗阻。在本研究中,我们报告了我们在治疗难治性CPO(提示为IV型协同失调,伴有肛门括约肌张力增加)方面的手术经验。
一名48岁男性,患有智力残疾、抑郁症、心力衰竭和终末期肾病,因CPO急性加重就诊。他有慢性便秘和腹胀病史。尽管进行了药物治疗和反复的结肠镜减压,但结肠扩张和排便困难仍持续存在。肛门测压结果显示为IV型协同失调,直肠压力增加。行哈特曼手术切除冗长的巨结肠,并避免排便时肛门括约肌压力增加。在切除的结肠中观察到神经节减少,这可能会使CPO的慢性病程恶化。
由于CPO的病理生理学尚未明确确定,因此治疗CPO患者需要细致的评估和谨慎的管理。难治性CPO患者需要适当的手术治疗。
由于存在肠穿孔风险,CPO需要细致的评估和谨慎的管理。需要进行精确评估以识别影响CPO伴发排便问题的其他因素,从而做出适当的治疗决策。