Tikkanen Ville, Siira Virva, Wahlberg Karl-Erik, Hakko Helinä, Myllyaho Toni, Läksy Kristian, Roisko Riikka, Niemelä Mika, Räsänen Sami
Faculty of Medicine, Research Unit of Clinical Neuroscience, University of Oulu, Psychiatry, P.O. Box 5000, Oulu 90014, Finland; Faculty of Education, Research Unit Values, Ideologies and Social Contexts of Education, University of Oulu, Oulu, Finland.
Faculty of Education, Research Unit Values, Ideologies and Social Contexts of Education, University of Oulu, Oulu, Finland.
Psychiatry Res. 2022 Oct;316:114793. doi: 10.1016/j.psychres.2022.114793. Epub 2022 Aug 14.
Social functioning deficits during adolescence are associated with later psychiatric morbidity, particularly in offspring at high genetic risk for schizophrenia spectrum disorders. However, a shortcoming of earlier study findings is the lack of control of the impact of the family rearing environment. The study was aimed to examine the association of adoptees' social functioning during adolescence, adoptive family functioning, and adoptees' high (HR) or low (LR) genetic risk for schizophrenia spectrum disorders with adoptees' later psychiatric morbidity. The present subsample from the nationwide Finnish Adoptive Family Study of Schizophrenia included 57 HR and 60 LR adoptees. Adolescent social functioning was assessed using UCLA Social Attainment Survey (UCLA SAS). Adoptive family functioning was based on Global Family Ratings (GFRs) and psychiatric disorders on DSM-III-R criteria. The results indicated that, after controlling for adoptive family functioning and genetic risk for schizophrenia spectrum disorders, deficits in peer relationships during adolescence were associated with an increased likelihood of psychiatric morbidity of adoptees. Our findings highlight social functioning deficits during adolescence, specifically in peer relationships, as plausible independent risk factors for later psychiatric disorders. These results can be utilized in identifying possible at-risk groups and targets for prevention and in developing preventive strategies.
青少年期的社会功能缺陷与后期的精神疾病发病率相关，尤其是在精神分裂症谱系障碍高遗传风险的后代中。然而，早期研究结果的一个缺点是缺乏对家庭养育环境影响的控制。本研究旨在探讨青少年期被收养者的社会功能、收养家庭功能以及被收养者患精神分裂症谱系障碍的高（HR）或低（LR）遗传风险与被收养者后期精神疾病发病率之间的关联。来自芬兰全国性精神分裂症收养家庭研究的当前子样本包括57名HR被收养者和60名LR被收养者。青少年社会功能使用加州大学洛杉矶分校社会成就调查（UCLA SAS）进行评估。收养家庭功能基于全球家庭评分（GFRs），精神疾病根据《精神疾病诊断与统计手册第三版修订版》（DSM-III-R）标准进行评定。结果表明，在控制了收养家庭功能和精神分裂症谱系障碍的遗传风险后，青少年期同伴关系缺陷与被收养者精神疾病发病率增加的可能性相关。我们的研究结果强调了青少年期的社会功能缺陷，特别是在同伴关系方面，是后期精神疾病可能的独立危险因素。这些结果可用于识别可能的高危人群和预防目标，并制定预防策略。
