Gumbmann M R, Friedman M
J Nutr. 1987 Jun;117(6):1018-23. doi: 10.1093/jn/117.6.1018.
Rat feeding studies showed that L-cystine, L-cysteine, N-acetyl-L-cysteine and L-methionine enhance the nutritional quality of raw (unheated) soy flour as measured in rats by the protein efficiency ratio (PER). Pancreas weights of rats fed diets supplemented with sulfur amino acids were higher than those of rats fed unsupplemented diets. In some instances this increase resulting from nutritional improvement of the diet was relatively greater than that in total body weight. Explanations are offered for these effects in terms of the proposed biofeedback mechanism involving the gastrointestinal endocrine system and the hormone cholecystokinin. The observed stimulation of pancreatic growth by added sulfur amino acids may be closely associated with this pancreatic regulatory mechanism when activated in response to dietary trypsin inhibitors present in unheated soy protein. The extent to which pancreatic hypertrophy develops as a result of a given exposure to trypsin inhibitors may be limited when the total amount or quality of the protein in the diet is less than optimal.
大鼠喂养研究表明，以蛋白质效率比（PER）衡量，L-胱氨酸、L-半胱氨酸、N-乙酰-L-半胱氨酸和L-蛋氨酸可提高生（未加热）大豆粉对大鼠的营养质量。喂食添加了含硫氨基酸日粮的大鼠胰腺重量高于喂食未添加日粮的大鼠。在某些情况下，由于日粮营养改善导致的这种增加相对大于总体重的增加。根据所提出的涉及胃肠内分泌系统和激素胆囊收缩素的生物反馈机制，对这些影响给出了解释。当因未加热大豆蛋白中存在的膳食胰蛋白酶抑制剂而激活时，观察到添加的含硫氨基酸对胰腺生长的刺激可能与这种胰腺调节机制密切相关。当日粮中蛋白质的总量或质量低于最佳水平时，由于一定程度接触胰蛋白酶抑制剂而导致的胰腺肥大发展程度可能会受到限制。
