Service d'oncologie radiothérapie, hôpital Tenon, AP-HP, Sorbonne université, institut universitaire de cancérologie, 4, rue de la Chine, Paris, France; Inserm U938 Cancer Biology and Therapeutics, centre de recherche Saint-Antoine, 75012 Paris, France.
Service d'oncologie radiothérapie, hôpital Tenon, AP-HP, Sorbonne université, institut universitaire de cancérologie, 4, rue de la Chine, Paris, France; Radiation Oncology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Cancer Radiother. 2022 Oct;26(6-7):858-864. doi: 10.1016/j.canrad.2022.06.020. Epub 2022 Aug 17.
Despite recent advances, the prognosis of pancreatic adenocarcinomas remains poor, even for patients with resectable tumors. For these latter, new approaches based on neoadjuvant treatment have been developed. Two components are used: chemotherapy and radiation therapy (RT). Indeed, pre-operative RT has many advantages in terms of efficacy and tolerance. It increases notably the chances of subsequent complete tumor resection. Several prospective trials are currently ongoing to clarify its place in the therapeutic arsenal. Another crucial question is to know which is the best RT technique: conventional normofractionated chemoradiotherapy or hypofrationated stereotactic body RT?
尽管最近取得了一些进展，但即使是可切除肿瘤的胰腺腺癌患者，其预后仍然很差。对于后者，已经开发了基于新辅助治疗的新方法。该方法使用了两种成分：化疗和放射治疗（RT）。事实上，术前 RT 在疗效和耐受性方面具有许多优势。它显著增加了随后完全肿瘤切除的机会。目前正在进行几项前瞻性试验，以阐明其在治疗武器库中的地位。另一个关键问题是要知道哪种 RT 技术最好：常规适形分割放化疗还是低分割立体定向体部 RT？
