Department of Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang, China.
Biomol Biomed. 2023 Feb 1;23(1):170-175. doi: 10.17305/bjbms.2022.7705.
We conducted a retrospective cohort study with the aim of investigating the relationship between subchorionic hematoma (SCH) and pregnancy outcomes in women with recurrent pregnancy loss (RPL). We reviewed all RPL patients who came to the Fourth Hospital of Shijiazhuang from January 2019 to June 2021. Two groups were divided according to the presence or absence of SCH. Live birth rate was considered as the primary outcome. Secondary outcomes included adverse pregnancy outcomes and complications. Univariable and multivariable analyses were conducted. Of 274 RPL women included in the final analysis, 49 (17.9%) had SCH. The occurrence of thrombophilia was significantly higher in SCH group than that in non-SCH group (38.8% vs 24.4%, P=0.041). There were no significant differences between the two groups in live birth rate, adverse pregnancy outcomes and pregnancy complications. Among women with SCH, live birth rate or SCH duration was not associated with continued use of low-dose aspirin (LDA) after the diagnosis of SCH. Our findings suggest that SCH does not reduce live birth rate in RPL women or increase the risk of adverse pregnancy outcomes or pregnancy complications. Continued use of LDA after the detection of a hematoma is unlikely to affect SCH duration or the live birth rate.
我们进行了一项回顾性队列研究，旨在探讨复发性妊娠丢失（RPL）女性中绒毛膜下血肿（SCH）与妊娠结局的关系。我们回顾了 2019 年 1 月至 2021 年 6 月期间到石家庄市第四医院就诊的所有 RPL 患者。根据是否存在 SCH 将患者分为两组。活产率被视为主要结局。次要结局包括不良妊娠结局和并发症。进行了单变量和多变量分析。最终分析纳入了 274 名 RPL 女性，其中 49 名（17.9%）存在 SCH。SCH 组血栓形成倾向的发生率明显高于非 SCH 组（38.8%比 24.4%，P=0.041）。两组的活产率、不良妊娠结局和妊娠并发症发生率无显著差异。在存在 SCH 的女性中，SCH 持续时间或活产率与 SCH 诊断后继续使用低剂量阿司匹林（LDA）无关。我们的研究结果表明，SCH 不会降低 RPL 女性的活产率，也不会增加不良妊娠结局或妊娠并发症的风险。SCH 检测后继续使用 LDA 不太可能影响 SCH 持续时间或活产率。
