多种阳离子对松果体N - 乙酰基转移酶（EC 2.3.1.5）和羟吲哚 - O - 甲基转移酶（EC 2.1.1.4）体外活性的影响。
Effect of various cations on the activity of pineal gland N-acetyltransferase (EC 2.3.1.5) and hydroxyindole-O-methyl transferase (EC 2.1.1.4) in vitro.
作者信息
Morton D J
出版信息
J Pineal Res. 1987;4(2):161-7. doi: 10.1111/j.1600-079x.1987.tb00852.x.
The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, and sodium initially stimulated NAT activity, and as the cation concentration increased inhibitory activity was observed. These differential effects on NAT activity may in some way be involved in pineal regulation of cation levels.
研究了各种阳离子对松果体羟吲哚 - O - 甲基转移酶（HIOMT）和N - 乙酰转移酶（NAT）活性的影响。铜抑制这两种酶，而钙和镁抑制HIOMT；目前这些抑制机制尚不清楚。钙、镁、钾和钠最初刺激NAT活性，随着阳离子浓度增加则观察到抑制活性。这些对NAT活性的不同影响可能在某种程度上参与了松果体对阳离子水平的调节。
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