Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Jan;15(1):e1842. doi: 10.1002/wnan.1842. Epub 2022 Aug 21.
The tumor microenvironment (TME) is a very cunning system that enables tumor cells to escape death post-traditional antitumor treatments through the comprehensive effect of different factors, thereby leading to drug resistance. Deep insights into TME characteristics and tumor resistance encourage the construction of nanomedicines that can remodel the TME against drug resistance. Tremendous interest in combining TME-regulation measurement with traditional tumor treatment to fight multidrug-resistant tumors has been inspired by the increasing understanding of the role of TME reconstruction in improving the antitumor efficiency of drug-resistant tumor therapy. This review focuses on the underlying relationships between specific TME characteristics (such as hypoxia, acidity, immunity, microorganisms, and metabolism) and drug resistance in tumor treatments. The exciting antitumor activities strengthened by TME regulation are also discussed in-depth, providing solutions from the perspective of nanomedicine design. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
肿瘤微环境（TME）是一个非常狡猾的系统，它通过不同因素的综合作用，使肿瘤细胞能够在传统抗肿瘤治疗后免于死亡，从而导致耐药性。深入了解 TME 特征和肿瘤耐药性，鼓励构建能够重塑 TME 以抵抗耐药性的纳米药物。随着对 TME 重构在提高耐药性肿瘤治疗抗肿瘤效率中的作用的认识不断加深，人们对将 TME 调节测量与传统肿瘤治疗相结合以对抗多药耐药肿瘤的兴趣大增。本综述重点关注特定 TME 特征（如缺氧、酸度、免疫、微生物和代谢）与肿瘤治疗中耐药性之间的潜在关系。还深入讨论了 TME 调节增强的令人兴奋的抗肿瘤活性，从纳米医学设计的角度提供了解决方案。本文属于以下类别： 治疗方法和药物发现 > 新兴技术 治疗方法和药物发现 > 用于肿瘤疾病的纳米医学 纳米技术在生物学中的应用 > 生物学中的纳米级系统
