脑小血管病患者中性粒细胞/淋巴细胞比值与认知障碍的相关性：一项回顾性研究。
Correlation between neutrophil/lymphocyte ratio and cognitive impairment in cerebral small vessel disease patients: A retrospective study.
作者信息
Hou Lan, Zhang Shuhan, Qi Dandan, Jia Tongle, Wang Huan, Zhang Wei, Wei Shuyan, Xue Conglong, Wang Pei
机构信息
Department of Neurology, Baoding No.1 Central Hospital, Baoding, China.
Baoding City Key Laboratory of Neurological Diseases, Baoding, China.
出版信息
Front Neurol. 2022 Aug 5;13:925218. doi: 10.3389/fneur.2022.925218. eCollection 2022.
BACKGROUND AND OBJECTIVE
The blood neutrophil/lymphocyte ratio (NLR) is an objective and convenient parameter of systemic inflammation. Elevated NLR is associated with an increased risk of mild cognitive impairment (CI) in the elderly. However, few data are available on the impact of the NLR on CI in patients with cerebral small vessel disease (CSVD).
METHODS
A total of 66 CSVD subjects with CI and 81 CSVD subjects without CI were evaluated in this study. Clinical, laboratory, radiological, and cognitive parameters were collected. The NLR was obtained with the absolute neutrophil count being divided by the absolute lymphocyte count in fasting blood samples. Logistic regression analysis was performed to evaluate the factors associated with CI. Receiver operating characteristic curves were illustrated to predict factors associated with CI in patients with CSVD.
RESULTS
The NLR of the CI group was significantly higher than that of subjects without CI (2.59 vs. 2.21, = 0.003). In multivariate analysis, NLR was positively correlated to the CI (OR: 1.43, 95% CI: 1.05-1.96, = 0.024). It was suggested that the optimum NLR cutoff point for CI was 1.89 with 69.7% sensitivity and 59.3% specificity. Subjects with NLR ≥ 1.89 showed higher possibilities of CI compared to those with NLR < 1.89 (OR: 3.38, 95% CI: 1.62-7.07).
CONCLUSIONS
Correlations were found between NLR and CI. Patients with CSVD who have higher NLR might have an increased risk of CI.
背景与目的
血液中性粒细胞/淋巴细胞比值（NLR）是全身炎症反应客观且便捷的参数。NLR升高与老年人轻度认知障碍（CI）风险增加相关。然而，关于NLR对脑小血管病（CSVD）患者CI影响的数据较少。
方法
本研究共评估了66例患有CI的CSVD受试者和81例未患CI的CSVD受试者。收集了临床、实验室、影像学和认知参数。通过空腹血样中绝对中性粒细胞计数除以绝对淋巴细胞计数得出NLR。进行逻辑回归分析以评估与CI相关的因素。绘制受试者工作特征曲线以预测CSVD患者中与CI相关的因素。
结果
CI组的NLR显著高于未患CI的受试者（2.59对2.21，P = 0.003）。多因素分析中，NLR与CI呈正相关（OR：1.43，95%CI：1.05 - 1.96，P = 0.024）。结果提示，CI的最佳NLR切点为1.89，敏感性为69.7%，特异性为59.3%。与NLR < 1.89的受试者相比，NLR≥1.89的受试者发生CI的可能性更高（OR：3.38，95%CI：1.62 - 7.07）。
结论
发现NLR与CI之间存在相关性。NLR较高的CSVD患者发生CI的风险可能增加。
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